Wray C, Roeder P L
Res Vet Sci. 1987 Mar;42(2):213-8.
The possibility that bovine virus diarrhoea virus (BVDV) infection could aggravate concurrent salmonella infections was investigated in two series of experiments with Salmonella dublin and S typhimurium. In both series of experiments the clinical signs tended to be more severe in dual infections than in those with salmonella alone. Faecal excretion of S dublin was similar in both single and dual infected calves. A protracted bacteraemia occurred only in two dual infected calves, one of which died from suppurative meningitis. In the case of S typhimurium, body temperatures, passage of abnormal faeces and isolation rates of salmonella from faeces were significantly increased. The results suggest that BVDV infection may indeed exacerbate the effects of salmonella infection and the aetiological relationship of the two agents should be considered during outbreaks of bovine salmonellosis.
在两项针对都柏林沙门氏菌和鼠伤寒沙门氏菌的系列实验中，研究了牛病毒性腹泻病毒（BVDV）感染加重并发沙门氏菌感染的可能性。在这两个系列实验中，双重感染的临床症状往往比单纯感染沙门氏菌的症状更严重。都柏林沙门氏菌在单重感染和双重感染的犊牛中的粪便排泄情况相似。仅在两头双重感染的犊牛中出现了持续性菌血症，其中一头死于化脓性脑膜炎。对于鼠伤寒沙门氏菌，体温、异常粪便的排出以及从粪便中分离出沙门氏菌的比率均显著增加。结果表明，BVDV感染可能确实会加剧沙门氏菌感染的影响，在牛沙门氏菌病暴发期间应考虑这两种病原体的病因关系。
