Kwon Sung Eun
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.
Front Syst Neurosci. 2018 Oct 9;12:47. doi: 10.3389/fnsys.2018.00047. eCollection 2018.
Measurements of population activity in alert animals have demonstrated that the intrinsic response state of the cortex has profound effects on the neuronal representation of sensory inputs, raising the possibility that cortical state could influence the behavioral performance in perceptual learning (PL). PL is a process by which sensory experience leads to gradual and semi-permanent improvements in perceptual judgment, and it is generally agreed that these improvements are modulated by sensory cortical areas. Although the precise neural mechanisms underlying the improved perceptual judgment remain unclear, cortical state has been shown to impact the behavioral outcome of PL. We discuss several ways in which cortical state might influence PL based on the recent evidence for state-dependent modulation of sensory encoding. Conversely, training in a certain perceptual task feeds back to modulate cortical state, suggesting a bi-directional relationship between cortical state and behavioral outcomes of PL. We highlight the recent studies that shed light on the mechanism of the interplay between cortical state and PL.
对警觉动物群体活动的测量表明，皮层的内在反应状态对感觉输入的神经元表征有深远影响，这增加了皮层状态可能影响感知学习（PL）中行为表现的可能性。PL是一个感觉经验导致感知判断逐渐且半永久性改善的过程，人们普遍认为这些改善是由感觉皮层区域调节的。尽管改善感知判断背后的确切神经机制尚不清楚，但皮层状态已被证明会影响PL的行为结果。基于最近关于感觉编码的状态依赖性调制的证据，我们讨论了皮层状态可能影响PL的几种方式。相反，在特定感知任务中的训练会反馈以调节皮层状态，这表明皮层状态与PL的行为结果之间存在双向关系。我们重点介绍了最近揭示皮层状态与PL之间相互作用机制的研究。
