Bussey H J
Semin Surg Oncol. 1987;3(2):67-70. doi: 10.1002/ssu.2980030204.
The emergence of familial polyposis coli from the general group of conditions with multiple polyps of the large intestine into a well-defined separate entity started when histopathology became a science. The recognition of its two main features--inheritance as a Mendelian dominant characteristic and its high incidence of associated colorectal cancer--greatly helped in establishing a policy of treatment designed to prevent cancer. The removal of all or most of the large intestine before cancer had supervened has had considerable success in reducing the cancer incidence. However, the more recent awareness that the adenomas can frequently be found also in the upper gastrointestinal tract has introduced new problems, the solution of which is currently a matter of investigation.
家族性腺瘤性息肉病从大肠多发性息肉这一总体病症类别中脱颖而出，成为一个明确界定的独立实体，始于组织病理学成为一门科学之时。对其两个主要特征的认识——作为孟德尔显性特征的遗传方式以及其相关结直肠癌的高发病率——极大地有助于制定旨在预防癌症的治疗策略。在癌症发生之前切除全部或大部分大肠在降低癌症发病率方面取得了相当大的成功。然而，最近人们意识到腺瘤也常常在上消化道中被发现，这带来了新的问题，目前这些问题的解决办法正在研究之中。
