北爱尔兰家族性腺瘤性息肉病的外科治疗
The surgical management of familial adenomatous polyposis in Northern Ireland.
作者信息
Campbell W J, Irwin S T, Parks T G
机构信息
Department of Surgery, Queen's University of Belfast, Belfast City Hospital.
出版信息
Ulster Med J. 1991 Oct;60(2):193-8.
Sixty-eight patients from 18 families have been identified as having familial adenomatous polyposis during the past 30 years in Northern Ireland (population 1.5 million). Six of the 18 probands (33%) had developed colonic carcinoma when first seen at mean age 34 years. Ten of the 44 patients identified by surgical screening (21%) at a significantly lower mean age of 23 years had colonic carcinoma. Surgical management has generally been by subtotal colectomy with ileorectal anastomosis, or by panproctocolectomy and ileostomy.
在过去30年里，北爱尔兰（人口150万）已确认18个家族中的68名患者患有家族性腺瘤性息肉病。18名先证者中有6名（33%）在初次就诊时平均年龄34岁时已发生结肠癌。通过手术筛查确诊的44名患者中，有10名（21%）在平均年龄显著更低的23岁时患有结肠癌。手术治疗通常采用次全结肠切除术加回肠直肠吻合术，或全直肠结肠切除术加回肠造口术。
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