Benenson E V, Nemtsov B F, Ualieva T M
Ter Arkh. 1987;59(4):76-9.
A comparative study of the cytostatic drugs prospidin and cyclophosphamide used in equal doses for rheumatoid arthritis (RA) is reported. Clinical and immunologic effects were determined, and the nature and incidence of side effects and complications were compared. Prospidin showed a more pronounced antirheumatic effect, making for a smaller daily requirement of nonsteroid anti-inflammatory agents or hormones in hormone-dependent cases. Unlike cyclophosphamide, prospidin was not associated with severe side effects and complications precluding further use of the drug. Both drugs demonstrated a regulatory effect on RA-associated immunologic disorders.
本文报道了对类风湿关节炎（RA）使用等量细胞抑制药物丙哌卡因和环磷酰胺的一项对比研究。测定了临床和免疫学效果，并比较了副作用和并发症的性质及发生率。丙哌卡因显示出更显著的抗风湿作用，在激素依赖型病例中使得非甾体抗炎药或激素的每日需求量更小。与环磷酰胺不同，丙哌卡因未出现严重副作用和并发症而妨碍该药物的进一步使用。两种药物均对RA相关的免疫紊乱表现出调节作用。
