Nemtsov B F, Benenson E V, Timina O V
Klin Med (Mosk). 1998;76(8):24-8.
Efficiency of pulse-therapy with prospidin (500 mg for 5 days in hospital, 500-1000 mg for a month as maintenance) and methotrexate (30 mg a week i.v. in hospital, 7-10 mg a week as maintenance) was investigated in 93 patients with severe RA. The response to prospidin and methotrexate arose quickly (within 10-14 and 4-5 weeks, respectively) and occurred in 73 and 70% of patients, respectively. Withdrawal of the drug was caused by side effects of methotrexate (19.3%) and resistance to prospidin (23.2%).
对93例重症类风湿关节炎（RA）患者研究了丙磺吡定脉冲疗法（住院期间5天内每日500毫克，维持期每月500 - 1000毫克）和甲氨蝶呤（住院期间每周静脉注射30毫克，维持期每周7 - 10毫克）的疗效。对丙磺吡定和甲氨蝶呤的反应出现迅速（分别在10 - 14周和4 - 5周内），分别有73%和70%的患者出现反应。停药原因是甲氨蝶呤的副作用（19.3%）和对丙磺吡定耐药（23.2%）。
