Kastl Gregor
Augenklinik Herzog Carl Theodor, Nymphenburger Str. 43, 80335, München, Deutschland.
Ophthalmologe. 2019 Aug;116(8):785-788. doi: 10.1007/s00347-018-0803-0.
Under a combination therapy with cobimetinib/vemurafenib for the treatment of BRAF-V600 positive metastatic melanoma, symptomatic or asymptomatic bilateral serous retinopathy can occur, which is reversible after dose reduction or treatment discontinuation. In the case presented the progress of bilateral serous retinopathy was documented by optical coherence tomography (OCT). After therapy discontinuation, subfoveal fluid levels varied until remission was reached six months later.
在使用考比替尼/维莫非尼联合治疗BRAF-V600阳性转移性黑色素瘤时，可能会出现有症状或无症状的双侧浆液性视网膜病变，在剂量减少或治疗中断后这种病变是可逆的。在本病例中，通过光学相干断层扫描（OCT）记录了双侧浆液性视网膜病变的进展。治疗中断后，黄斑下液平面一直变化，直到六个月后病情缓解。
