Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Faculty of Science, Stem Cell Institute, Ankara University, Ankara, Turkey.
Biovalda Health Technologies, Inc., Ankara, Turkey.
Adv Exp Med Biol. 2018;1078:135-153. doi: 10.1007/978-981-13-0950-2_8.
Intrinsically conductive polymer nanocomposites have a remarkable potential for cellular applications such as biosensors, drug delivery systems, cell culture systems and tissue engineering biomaterials. Intrinsically conductive polymers transmit electrical stimuli between cells, and induce regeneration of electroactive tissues such as muscle, nerve, bone and heart. However, biocompatibility and processability are common issues for intrinsically conductive polymers. Conductive polymer composites are gaining importance for tissue engineering applications due to their excellent mechanical, electrical, optical and chemical functionalities. Here, we summarize the different types of intrinsically conductive polymers containing electroactive nanocomposite systems. Cellular applications of conductive polymer nanocomposites are also discussed focusing mainly on poly(aniline), poly(pyrrole), poly(3,4-ethylene dioxythiophene) and poly(thiophene).
本征导电聚合物纳米复合材料在细胞应用方面具有显著的潜力，例如生物传感器、药物输送系统、细胞培养系统和组织工程生物材料。本征导电聚合物在细胞之间传递电刺激，并诱导诸如肌肉、神经、骨骼和心脏等电活性组织的再生。然而，生物相容性和可加工性是本征导电聚合物的常见问题。导电聚合物复合材料因其优异的机械、电气、光学和化学功能而在组织工程应用中受到重视。在这里，我们总结了不同类型的含有电活性纳米复合材料系统的本征导电聚合物。本文还讨论了导电聚合物纳米复合材料的细胞应用，主要集中在聚（苯胺）、聚（吡咯）、聚（3,4-亚乙基二氧噻吩）和聚（噻吩）上。
