Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul, South Korea.
Wastewater Technology Division, CSIR-National Environmental Engineering Research Institute, Nagpur, Maharashtra, India.
Adv Exp Med Biol. 2018;1078:303-320. doi: 10.1007/978-981-13-0950-2_16.
Various commercial vaccines are used for immunization against hepatitis B. However, these immunotherapeutic vaccines require invasive administration, which can induce side effects, and require multiple shots to elicit an immune response, limiting their efficacy. Compared to traditional hepatitis B vaccines, polymer nanoparticles have more advantageous inherent properties as vaccine delivery carriers, providing increased stability of encapsulated antigen, the possibility of single-shot immunotherapy, and the capability of mucosal administration, which allows various routes of vaccination. In this review, we present up-to-date information on the potential of a biodegradable nanoparticle-based delivery system in treating hepatitis B. We also discuss the application of nanoparticles in various vaccines and highlighted strategies for eliciting an appropriate immune response.
各种商业疫苗被用于预防乙型肝炎。然而，这些免疫治疗疫苗需要进行侵入性给药，这可能会引起副作用，并且需要多次注射才能引发免疫反应，限制了它们的疗效。与传统的乙型肝炎疫苗相比，聚合物纳米粒子作为疫苗递送载体具有更多有利的固有特性，为封装抗原提供了更高的稳定性，有可能进行单次免疫治疗，并且能够进行黏膜给药，允许各种途径的接种。在这篇综述中，我们介绍了基于可生物降解纳米粒子的递药系统在治疗乙型肝炎方面的最新信息。我们还讨论了纳米粒子在各种疫苗中的应用，并强调了引发适当免疫反应的策略。
