胶原 I 型：一种多功能生物材料。
Collagen Type I: A Versatile Biomaterial.
机构信息
Tissue Engineering Centre, Faculty of Medicine, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Bioartificial Organ and Regenerative Medicine Unit, National Defence University of Malaysia, Kuala Lumpur, Malaysia.
出版信息
Adv Exp Med Biol. 2018;1077:389-414. doi: 10.1007/978-981-13-0947-2_21.
Collagen type I is the most abundant matrix protein in the human body and is highly demanded in tissue engineering, regenerative medicine, and pharmaceutical applications. To meet the uprising demand in biomedical applications, collagen type I has been isolated from mammalians (bovine, porcine, goat and rat) and non-mammalians (fish, amphibian, and sea plant) source using various extraction techniques. Recent advancement enables fabrication of collagen scaffolds in multiple forms such as film, sponge, and hydrogel, with or without other biomaterials. The scaffolds are extensively used to develop tissue substitutes in regenerating or repairing diseased or damaged tissues. The 3D scaffolds are also used to develop in vitro model and as a vehicle for delivering drugs or active compounds.
胶原蛋白 I 型是人体内最丰富的基质蛋白，在组织工程、再生医学和药物应用中需求量很大。为了满足生物医学应用的增长需求，已经使用各种提取技术从哺乳动物（牛、猪、山羊和大鼠）和非哺乳动物（鱼、两栖动物和海生植物）来源中分离出胶原蛋白 I 型。最近的进展使得可以使用多种形式（例如膜、海绵和水凝胶）制造胶原蛋白支架，也可以与其他生物材料一起使用。这些支架被广泛用于开发组织替代品，以再生或修复患病或受损的组织。3D 支架还被用于开发体外模型和作为输送药物或活性化合物的载体。
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