Blagodatskiĭ M D, Balashov B B
Zh Nevropatol Psikhiatr Im S S Korsakova. 1987;87(4):512-6.
Study of biopsy material obtained from 612 surgical patients with vertebrogenic diseases of spinal radicles at the lumbosacral level and collation of the morphologic findings with the clinical picture of the disease revealed a correlation between the clinical manifestations and the inflammatory process in the vascularized tissues of the vertebral column. The severity of pain was found to depend on the degree of inflammatory changes in the epidural cellular tissue and spinal membranes. The frequency and severity of inflammatory reactions make it possible to consider inflammation, along with compression and ischemia, an important pathogenetic mechanism of the development, progression and course of the discogenic radicular syndrome and to recommend the inclusion of antiinflammatory drugs in multiple modality treatment of the disease as a method of pathogenetic therapy.
对612例腰骶部脊神经根性脊椎疾病手术患者的活检材料进行研究，并将形态学检查结果与疾病临床表现进行对照，结果显示临床表现与脊柱血管化组织中的炎症过程之间存在相关性。发现疼痛的严重程度取决于硬膜外细胞组织和脊膜炎症变化的程度。炎症反应的频率和严重程度使我们有可能认为，炎症与压迫和缺血一样，是椎间盘源性神经根综合征发生、发展和病程的重要发病机制，并建议在该疾病的多模式治疗中加入抗炎药物作为一种发病机制疗法。
