Pavlík A, Benesová O, Dlohozková N
Act Nerv Super (Praha). 1987 Mar;29(1):62-5.
High affinity choline uptake (HACU) in the hippocampus and striatal concentration of dopamine (DA) and homovanillic acid (HVA) as measures of the in vivo acetylcholine and DA turnover, respectively, were estimated in male rats, Long-Evans, following 6-day administration of various nootropics in clinically relevant doses: piracetam and its derivatives pramiracetam and oxiracetam (100 mg/kg/day), pyritinol (50 mg/kg/day). Piracetam treatment was without effect on HACU, but induced significant increase of HVA in the striatum leaving striatal DA concentration unchanged. On the contrary, pyritinol, pramiracetam and oxiracetam increased HACU, but did not change striatal DA and HVA levels.
在雄性 Long-Evans 大鼠中，以海马体中的高亲和力胆碱摄取（HACU）以及纹状体中多巴胺（DA）和高香草酸（HVA）的浓度分别作为体内乙酰胆碱和 DA 周转率的指标，在给予各种临床相关剂量的促智药 6 天后进行了评估：吡拉西坦及其衍生物普拉西坦和奥拉西坦（100 毫克/千克/天）、吡硫醇（50 毫克/千克/天）。吡拉西坦治疗对 HACU 无影响，但可使纹状体中的 HVA 显著增加，而纹状体 DA 浓度不变。相反，吡硫醇、普拉西坦和奥拉西坦可增加 HACU，但不改变纹状体 DA 和 HVA 水平。
