Dipartimento di Medicina Sperimentale, Università di Roma "Sapienza".
Clin Nucl Med. 2018 Dec;43(12):e492-e494. doi: 10.1097/RLU.0000000000002331.
We report the case of a 43-year-old man with a history of lung carcinoid and a recent detection of thyroid nodules by ultrasound. The cytological analysis raised the suspicion of medullary thyroid carcinoma; however, calcitonin and carcinoembryonic antigen levels were in reference range. Considering the previous diagnosis of lung carcinoid, the patient underwent whole-body Ga-DOTATOC PET/CT. The images showed focal radiopharmaceutical uptake in both thyroid lobes. After thyroidectomy, the histology and immunohistochemistry (negative for calcitonin and positive for chromogranin A) confirmed the neuroendocrine origin of the thyroid nodules, possibly referable to previous lung carcinoid.
我们报告了一例 43 岁男性病例，该患者患有肺类癌，并在近期通过超声检查发现甲状腺结节。细胞学分析提示为甲状腺髓样癌的可能性大，但降钙素和癌胚抗原水平处于参考范围内。鉴于之前诊断为肺类癌，患者进行了全身 Ga-DOTATOC PET/CT 检查。图像显示双侧甲状腺叶有放射性药物摄取的焦点。甲状腺切除术后，组织学和免疫组织化学（降钙素阴性，嗜铬粒蛋白 A 阳性）证实甲状腺结节的神经内分泌起源，可能与之前的肺类癌有关。
