Department of General Surgery, All India Institute of Medical Sciences, New Delhi, India.
Korean J Intern Med. 2010 Dec;25(4):386-91. doi: 10.3904/kjim.2010.25.4.386. Epub 2010 Nov 27.
BACKGROUND/AIMS: Although carcinoid tumors usually have good prognosis, early and specific diagnosis is important. Computed tomography and magnetic resonance imaging do not provide findings that are specific for carcinoids, and somatostatin receptor scintigraphy suffers from low spatial resolution. 18-Fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) has limited sensitivity for carcinoids due to low uptake of the marker. A PET/CT system that uses the somatostatin receptor-based PET tracer 1,4,7,10-tetraazacyclododecane-N(I),N(II),N(III),N(IIII)-tetraacetic acid (D)-Phe(1)-thy(3)-octreotide ((68)Ga-DOTATOC) has also been used in the evaluation of carcinoids, although information regarding its use for the detection of primary pulmonary carcinoids is limited. Thus, we investigated the value of (68)Ga-DOTATOC PET/CT for the diagnosis of primary pulmonary carcinoid tumors.
This was a retrospective analysis of patients with primary pulmonary tumors who underwent (68)Ga-DOTATOC PET/CT. All the patients had a histopathologic diagnosis of carcinoid. The rate of detection of primary pulmonary carcinoid tumors using (68)Ga-DOTATOC PET/CT was assessed.
Twenty patients were diagnosed as having carcinoid, and 19 tumors showed significant uptake on (68)Ga-DOTATOC (detection rate, 95%). The maximal standardized uptake value (SUV(max)) ranged from 1.1 to 66, with a median value of 21.6. In one patient, (68)Ga-DOTATOC PET/CT revealed additional lesions.
Our results demonstrate that (68)Ga-DOTATOC PET/CT is useful in the evaluation of primary pulmonary carcinoids and should be included in the diagnostic work-up of these patients.
背景/目的：尽管类癌肿瘤通常预后良好，但早期和特异性诊断很重要。计算机断层扫描和磁共振成像并不能提供类癌的特异性发现，而生长抑素受体闪烁显像的空间分辨率较低。由于标志物摄取率低，18-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）对类癌的敏感性有限。使用基于生长抑素受体的 PET 示踪剂 1,4,7,10-四氮杂环十二烷-N（I），N（II），N（III），N（IV）-四乙酸（D）-Phe（1）-Thy（3）-奥曲肽（68Ga-DOTATOC）的 PET/CT 系统也已用于类癌的评估，尽管有关其用于检测原发性肺类癌的信息有限。因此，我们研究了 68Ga-DOTATOC PET/CT 用于诊断原发性肺类癌肿瘤的价值。
这是一项回顾性分析接受 68Ga-DOTATOC PET/CT 检查的原发性肺肿瘤患者的研究。所有患者均经组织病理学诊断为类癌。评估 68Ga-DOTATOC PET/CT 检测原发性肺类癌肿瘤的检出率。
20 例患者被诊断为类癌，19 个肿瘤在 68Ga-DOTATOC 上显示明显摄取（检出率为 95%）。最大标准化摄取值（SUV（max））范围为 1.1 至 66，中位数为 21.6。在一名患者中，68Ga-DOTATOC PET/CT 显示了其他病变。
我们的结果表明，68Ga-DOTATOC PET/CT 可用于评估原发性肺类癌，应将其纳入此类患者的诊断程序中。
