Department of Obstetrics & Gynecology, University of British Columbia, Vancouver, BC, Canada.
Centre for Health Services and Policy Research, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
BMC Cancer. 2018 Oct 25;18(1):1039. doi: 10.1186/s12885-018-4970-9.
Among women with epithelial ovarian cancer (EOC), histotype is one of the major prognostic factors. However, few data are available on histotype- specific survival and mortality estimates among these patients. We therefore examined survival and causes of death among women with EOC by histotype.
A population- based cohort including all ovarian cancer patients diagnosed in British Columbia (BC) between 1990 and 2014 was built using population-based administrative datasets. We compared causes of death within histotypes, by age at diagnosis, BRCA status, and time since diagnosis.
A total of 6975 women were identified as having been diagnosed with EOC between 1990 and 2014 in BC. The most common cause of death among these women was ovarian cancer until 10 years post diagnosis when other causes surpassed ovarian cancer as the leading cause of death. Among women with serous EOCs, ovarian cancer was the leading cause of death 12 years after diagnosis, whereas ovarian cancer was the leading cause of death for 8 years among women with non- serous EOCs. Among women with serous EOCs, ovarian cancer was the leading cause of death for 12 years among younger women (< 60 years of age) compared to 8 years among women > = 60 years of age, and those with BRCA mutations were more likely to die from ovarian cancer than those without a BRCA mutation.
Within 10 years from diagnosis, ovarian cancer is the leading cause of death among women diagnosed with EOC.
在患有上皮性卵巢癌（EOC）的女性中，组织学类型是主要的预后因素之一。然而，关于这些患者的组织学类型特异性生存和死亡率估计数据很少。因此，我们通过组织学类型检查了患有 EOC 的女性的生存和死亡原因。
使用基于人群的行政数据集构建了一个包括 1990 年至 2014 年期间在不列颠哥伦比亚省（BC）诊断出的所有卵巢癌患者的基于人群的队列。我们比较了不同组织学类型、诊断时年龄、BRCA 状态和诊断后时间内的死亡原因。
共确定了 6975 名女性在 1990 年至 2014 年期间在 BC 被诊断为患有 EOC。这些女性中最常见的死亡原因是卵巢癌，直到诊断后 10 年，其他原因超过卵巢癌成为主要死亡原因。在患有浆液性 EOC 的女性中，卵巢癌是诊断后 12 年的主要死亡原因，而在非浆液性 EOC 的女性中，卵巢癌是主要死亡原因 8 年。在患有浆液性 EOC 的年轻女性（<60 岁）中，卵巢癌是 12 年内的主要死亡原因，而在年龄较大的女性（≥60 岁）中则为 8 年，且携带 BRCA 突变的女性比未携带 BRCA 突变的女性更有可能死于卵巢癌。
在诊断后 10 年内，卵巢癌是诊断为 EOC 的女性的主要死亡原因。
