Tadege Melaku
Department of Statistics, Injibara University, Injibara, Amhara, Ethiopia.
BMC Res Notes. 2018 Oct 25;11(1):761. doi: 10.1186/s13104-018-3863-y.
The purpose of this study was to identify the major risk factors, which contributed to shortened survival time to death of HIV patients on antiretroviral therapy. Six-hundred HIV patients were included from two hospitals and six health centers record from January 2003 to December 2017. Kaplan-Meier and Cox proportional hazard model were implemented.
From the Kaplan-Meier, log-rank test result indicated that there was a significant difference between tuberculosis comorbidity (P = .000), occupation (P = .027), and WHO clinical stage (P = .012) on the survival experience of patients at 5% statistical significance level. From the Cox regression result, the risk of death for patients who lived with tuberculosis was about 2.872-fold times higher than those patients who were negative. Most of the HIV/AIDS patients on antiretroviral therapy were died in a short period due to tuberculosis comorbidity, began with lower amount of CD4, being underweight, merchant, and being on WHO clinical stage IV.
本研究旨在确定导致接受抗逆转录病毒治疗的艾滋病患者生存时间缩短至死亡的主要风险因素。纳入了2003年1月至2017年12月期间两家医院和六个健康中心记录的600例艾滋病患者。采用了Kaplan-Meier法和Cox比例风险模型。
从Kaplan-Meier曲线来看，对数秩检验结果表明，在5%的统计学显著性水平上，合并结核病（P = 0.000）、职业（P = 0.027）和世界卫生组织临床分期（P = 0.012）对患者的生存经历有显著差异。从Cox回归结果来看，合并结核病的患者死亡风险比未合并结核病的患者高出约2.872倍。大多数接受抗逆转录病毒治疗的艾滋病患者因合并结核病在短期内死亡，这些患者初始CD4细胞数量较低、体重过轻、从事商业活动且处于世界卫生组织临床IV期。
