Wilson Nick, Jones Amanda C, Nghiem Nhung, Blakely Tony
Department of Public Health, University of Otago Wellington, Wellington.
N Z Med J. 2018 Oct 26;131(1484):61-67.
There is new evidence from a very large systematic review and meta-analysis (Navarese et al 2018), that using statins for reducing levels of low-density lipoprotein cholesterol reduces the risk of premature death. In this viewpoint article we consider the implications of this new evidence for New Zealand but also examine how the use of statins may be improved for primary prevention of cardiovascular disease (CVD) in this country. We suggest the need to explore such options as fixed-dose combination pills containing statins, three-drug polypills, behind-the-counter dispensing and six-month prescriptions. But in addition to pharmacological prevention of CVD, there is a need for improved population-wide changes to the environment. These include adopting policies to improve tobacco control, the nutrition environment (eg, particularly around sodium), alcohol control and making walking and cycling easier options.
一项大规模系统评价和荟萃分析(纳瓦雷塞等人,2018年)有新证据表明,使用他汀类药物降低低密度脂蛋白胆固醇水平可降低过早死亡风险。在这篇观点文章中,我们考虑了这一新证据对新西兰的影响,同时也探讨了如何在该国更好地使用他汀类药物以进行心血管疾病(CVD)的一级预防。我们建议探索一些选项,如含他汀类药物的固定剂量复方药丸、三联复方药丸、非处方配药和六个月的处方。但除了对CVD进行药物预防外,还需要在全人群范围内改善环境。这些措施包括采取政策加强烟草控制、改善营养环境(例如,特别是围绕钠的摄入)、酒精控制以及使步行和骑自行车成为更便捷的出行选择。