内皮素-1（ET-1）、前心房利钠肽（NTpro-ANP）的 N 端片段和肿瘤坏死因子-α（TNF-α）在原发性高血压和肾性高血压儿童中的变化。

Endothelin-1 (ET-1), N-terminal fragment of pro-atrial natriuretic peptide (NTpro-ANP), and tumour necrosis factor alpha (TNF-α) in children with primary hypertension and hypertension of renal origin.

机构信息

Department of Paediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland.

Department of Medical and Molecular Biology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland.

出版信息

Endokrynol Pol. 2019;70(1):37-42. doi: 10.5603/EP.a2018.0079. Epub 2018 Oct 25.

DOI:10.5603/EP.a2018.0079

PMID:30359461

Abstract

INTRODUCTION

Hypertension is regarded as a condition of mild inflammation and endothelial imbalance. The aim of the study was to evaluate serum concentrations of biomarkers of inflammation and endothelial function: tumour necrosis factor alpha (TNF-α), endothelin-1 (ET-1), and N-terminal fragment of pro-atrial natriuretic peptide (NTpro-ANP) in hypertensive and normotensive children.

MATERIAL AND METHODS

We studied 63 children aged 13.56 ± 3.73 years, divided into two groups: a group with primary hypertension (n = 50) and a group with renal hypertension (n = 13). The control group consisted of 34 normotensive children aged 12.76 ± 3.96 years. Biomarkers were measured with ELISA tests.

RESULTS

ET-1 levels were significantly higher in primary hypertension (9.93 ± 1.73 pg/ml) and renal hypertension (10.77 ± 1.50 pg/ml) in comparison to controls (4.03 ± 0.97 pg/ml), (p < 0.001, p < 0.001, respectively). NT-pro ANP concentrations in primary hypertension (71.03 ± 10.02 pg/ml), and renal hypertension (84.78 ± 6.44 pg/ml) were significantly higher than in the control group (29.62 ± 5.56 pg/ml) (p < 0.001, p < 0.001, respectively). TNF-α concentrations in primary hypertension (8.36 ± 1.60 pg/ml) and renal hypertension (7.35 ± 0.93 pg/ml) significantly exceeded concentrations in controls (4.49 ± 0.93 pg/ml), (p < 0.001, p < 0.001, respectively). ET-1 and NT-pro ANP concentrations in renal hypertension significantly exceeded those in primary hypertension (p = 0.049, p < 0.001, respectively) while TNF-α levels in renal hypertension were significantly lower than in primary hypertension (p = 0.046).

CONCLUSIONS

The results of our study show that ET-1, NT-pro ANP, and TNF-a concentrations are increased in hypertension in children. Our investigation indicates significant importance of inflammation and endothelial involvement in hypertension in youth.

摘要

简介

高血压被认为是一种轻度炎症和内皮失衡的状态。本研究旨在评估炎症和内皮功能的生物标志物在高血压和正常血压儿童中的血清浓度：肿瘤坏死因子-α（TNF-α）、内皮素-1（ET-1）和氨基末端脑钠肽前体（NTpro-ANP）。

材料与方法

我们研究了 63 名年龄为 13.56 ± 3.73 岁的儿童，分为两组：原发性高血压组（n = 50）和肾性高血压组（n = 13）。对照组由 34 名年龄为 12.76 ± 3.96 岁的正常血压儿童组成。生物标志物采用 ELISA 法检测。

结果

原发性高血压组（9.93 ± 1.73 pg/ml）和肾性高血压组（10.77 ± 1.50 pg/ml）的 ET-1 水平明显高于对照组（4.03 ± 0.97 pg/ml）（p < 0.001，p < 0.001）。原发性高血压组（71.03 ± 10.02 pg/ml）和肾性高血压组（84.78 ± 6.44 pg/ml）的 NT-pro ANP 浓度明显高于对照组（29.62 ± 5.56 pg/ml）（p < 0.001，p < 0.001）。原发性高血压组（8.36 ± 1.60 pg/ml）和肾性高血压组（7.35 ± 0.93 pg/ml）的 TNF-α浓度明显高于对照组（4.49 ± 0.93 pg/ml）（p < 0.001，p < 0.001）。肾性高血压组的 ET-1 和 NT-pro ANP 浓度明显高于原发性高血压组（p = 0.049，p < 0.001），而肾性高血压组的 TNF-α水平明显低于原发性高血压组（p = 0.046）。