Cardiovascular Engineering, Incorporated, Norwood, Massachusetts.
J Appl Physiol (1985). 2018 Dec 1;125(6):1871-1880. doi: 10.1152/japplphysiol.00108.2018. Epub 2018 Oct 25.
Measures of aortic stiffness and pressure and flow pulsatility have emerged as correlates of and potential contributors to cardiovascular disease, dementia, and kidney disease. Higher aortic stiffness and greater pressure and flow pulsatility are associated with excessive pulsatile load on the heart, which increases mass and reduces global longitudinal strain of the left ventricle. Excessive stiffness and pulsatility are also associated with microvascular lesions in high-flow organs, such as the brain and kidney, suggesting that small vessels in these organs are damaged by pulsatility. This brief review will summarize evidence relating aortic stiffness to cardiovascular, brain, and kidney disease.
主动脉僵硬度和压力及血流搏动性的测量已经成为心血管疾病、痴呆和肾脏疾病的相关因素和潜在致病因素。较高的主动脉僵硬度和更大的压力及血流搏动性与心脏承受过大的搏动性负荷相关，这会增加心脏质量并降低左心室的整体纵向应变。僵硬度和搏动性过高还与高流量器官（如大脑和肾脏）的微血管病变相关，这表明这些器官的小血管受到了搏动性的损伤。这篇简短的综述将总结主动脉僵硬度与心血管、大脑和肾脏疾病的关系的证据。
