利用三维类器官构建脑疾病模型。

Building Models of Brain Disorders with Three-Dimensional Organoids.

机构信息

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.

出版信息

Neuron. 2018 Oct 24;100(2):389-405. doi: 10.1016/j.neuron.2018.10.007.

DOI:10.1016/j.neuron.2018.10.007

Abstract

Disorders of the nervous system are challenging to study and treat due to the relative inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human brain organoids have the potential to recapitulate features of the human brain with greater complexity than 2D models and are increasingly being applied to model diseases affecting the central nervous system. Here, we review the use of human brain organoids to investigate neurological and psychiatric (neuropsychiatric) disorders and how this technology may ultimately advance our biological understanding of these conditions.

摘要

神经系统疾病由于功能性人脑组织难以用于研究，因此研究和治疗具有挑战性。源自干细胞的 3D 人脑类器官具有比 2D 模型更高的复杂性来重现人脑特征的潜力，并且越来越多地被应用于模拟影响中枢神经系统的疾病。在这里，我们回顾了使用人脑类器官来研究神经和精神疾病（神经精神疾病）的情况，以及这项技术最终如何促进我们对这些疾病的生物学理解。