Kato H, Inoue S, Takahashi K, Yamanaka A, Okada Y
Gan To Kagaku Ryoho. 1987 Jun;14(6 Pt 1):1866-70.
The concentrations of FT, 5-FU and uracil in lung cancer tissue, healthy lung tissue and serum were measured in 10 patients with primary lung cancer to whom UFT (600 mg) had been administered for one week. No remarkable difference was found in the concentration of FT between both tissues. The concentration of 5-FU in lung cancer tissue was 0.099 +/- 0.051 microgram/g and significantly higher than the level of 0.009 +/- 0.003 microgram/ml in serum (p less than 0.001) and 0.039 +/- 0.021 microgram/g in normal lung tissue (p less than 0.01). The ratio of 5-FU concentration in cancerous tissue to that in the serum was 11.0, while the ratio of the level in cancerous tissue to that in normal lung tissue was 2.5. The concentration of uracil was much higher in cancerous tissue than in normal lung tissue and serum. Maintenance therapy with UFT proved possible for a long period in 11 primary lung cancer patients with negligible digestive side effects.
对10例接受优福定（600毫克）治疗一周的原发性肺癌患者，测定了其肺癌组织、健康肺组织及血清中FT、5-氟尿嘧啶（5-FU）和尿嘧啶的浓度。两种组织中FT的浓度未发现显著差异。肺癌组织中5-FU的浓度为0.099±0.051微克/克，显著高于血清中0.009±0.003微克/毫升的水平（p<0.001）以及正常肺组织中0.039±0.021微克/克的水平（p<0.01）。癌组织中5-FU浓度与血清中浓度之比为11.0，而癌组织中水平与正常肺组织中水平之比为2.5。癌组织中尿嘧啶的浓度远高于正常肺组织和血清。11例原发性肺癌患者长期进行优福定维持治疗，消化副作用可忽略不计。
