酰化氨基寡糖对链霉菌 HO1518 来源的α-淀粉酶的抑制作用
Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518.
机构信息
Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
University of Chinese Academy of Sciences, Beijing 100039, China.
出版信息
Mar Drugs. 2018 Oct 23;16(11):403. doi: 10.3390/md16110403.
Five new acylated aminooligosaccharides (⁻), together with one known related analogue (), were isolated from sp. HO1518. Their structure was identified by extensive spectroscopic analysis, including 1D and 2D NMR data and high resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with those reported in the literature. All of the new compounds showed more promising porcine pancreatic -amylase (PPA) inhibitory activities than the clinical drug acarbose, indicating them as potential pharmaceutical drug leads toward type II diabetes.
从 sp. HO1518 中分离得到五个新的酰化氨基寡糖（⁻）和一个已知的相关类似物（）。通过广泛的光谱分析，包括 1D 和 2D NMR 数据和高分辨率电喷雾电离质谱（HRESIMS），以及与文献中报道的化合物进行比较，确定了它们的结构。所有新化合物对猪胰α-淀粉酶（PPA）的抑制活性均强于临床药物阿卡波糖，表明它们可能是治疗 II 型糖尿病的潜在药物先导化合物。
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