Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
University of Chinese Academy of Sciences, Beijing 100039, China.
Mar Drugs. 2021 Jun 21;19(6):350. doi: 10.3390/md19060350.
Microbial oligosaccharides have been regarded as one of the most appealing natural products attributable to their potent and selective bioactivities, such as antimicrobial activity, inhibition of α-glucosidases and lipase, interference of cellular recognition and signal transduction, and disruption of cell wall biosynthesis. Accordingly, a handful of bioactive oligosaccharides have been developed for the treatment of bacterial infections and type II diabetes mellitus. Given that naturally occurring oligosaccharides have increasingly gained recognition in recent years, a comprehensive review is needed. The current review highlights the chemical structures, biological activities and divergent biosynthetic origins of three subgroups of oligomers including the acarviosine-containing oligosaccharides, saccharomicins, and orthosomycins.
微生物低聚糖因其强大而具有选择性的生物活性，如抗菌活性、α-葡萄糖苷酶和脂肪酶抑制作用、细胞识别和信号转导干扰以及细胞壁生物合成的破坏作用，被认为是最有吸引力的天然产物之一。因此，已经有一些具有生物活性的低聚糖被开发用于治疗细菌感染和 II 型糖尿病。鉴于天然存在的低聚糖近年来越来越受到重视，因此需要进行全面的综述。本综述重点介绍了包含阿卡维辛的低聚糖、沙克米辛和正交霉素的三个亚类寡聚物的化学结构、生物活性和不同的生物合成来源。
