卡利什海绵酸：来自热带东太平洋海绵 Callyspongia cf. californica 的两亲性二酸。
Callyspongidic Acids: Amphiphilic Diacids from the Tropical Eastern Pacific Sponge Callyspongia cf. californica.
机构信息
Marine Biodiscovery, School of Chemistry and Ryan Institute , National University of Ireland Galway (NUI Galway) , University Road , H91 TK33 Galway , Ireland.
ESPOL Escuela Superior Politécnica del Litoral, Centro Nacional de Acuacultura e Investigaciones Marinas , Campus Gustavo Galindo km. 30.5 vía Perimetral, P.O. Box 09-01-5863 Guayaquil , Ecuador.
出版信息
J Nat Prod. 2018 Oct 26;81(10):2301-2305. doi: 10.1021/acs.jnatprod.8b00683. Epub 2018 Oct 15.
The first chemical study of the marine sponge Callyspongia cf. californica widely distributed along the coasts of the Tropical Eastern Pacific led to the identification of a new family of amphiphilic derivatives called callyspongidic acids. The four isolated metabolites 1-4 feature a hydrophilic diacid end opposed to both an aromatic moiety and a long alkyl chain. They were evaluated against a panel of pathogenic microbes and seven tumoral cell lines, displaying moderate inhibitory properties against the A2058 melanoma cell line with an IC of 3.2 μM for callyspongidic acid C13:0 (2).
对广泛分布于热带东太平洋沿岸的海绵 Callyspongia cf. californica 的首次化学研究导致了一类新的两亲性衍生物的鉴定，称为 callyspongidic 酸。分离得到的四种代谢产物 1-4 具有亲水二酸末端，分别与芳香部分和长烷基链相对。它们被评估用于一系列致病微生物和七种肿瘤细胞系，对 A2058 黑色素瘤细胞系显示出中等抑制活性，其中 C13:0（2）的 callyspongidic 酸的 IC 为 3.2 μM。
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