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物种：次生代谢产物、药理活性及作用机制。

spp.: Secondary Metabolites, Pharmacological Activities, and Mechanisms.

作者信息

Hadisaputri Yuni Elsa, Nurhaniefah Annida Adha, Sukmara Sendi, Zuhrotun Ade, Hendriani Rini, Sopyan Iyan

机构信息

Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, Indonesia.

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, Indonesia.

出版信息

Metabolites. 2023 Feb 1;13(2):217. doi: 10.3390/metabo13020217.

DOI:10.3390/metabo13020217
PMID:36837836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9964934/
Abstract

One of the most widespread biotas in the sea is the sponge. is a sponge genus found in the seas, making it easily available. In this review, the pharmacological activity and mechanism of action of the secondary metabolites of spp. are addressed, which may lead to the development of new drugs and targeted therapeutic approaches. Several scientific databases, such as Google Scholar, PubMed, ResearchGate, Science Direct, Springer Link, and Wiley Online Library, were mined to obtain relevant information. In the 41 articles reviewed, spp. was reported to possess pharmacological activities such as cytotoxicity against cancer cell lines (36%), antifungal (10%), anti-inflammatory (10%), immunomodulatory (10%), antidiabetic and antiobesity (6%), antimicrobial (8%), antioxidant (4%), antineurodegenerative (4%), antihypercholesterolemic (2%), antihypertensive (2%), antiparasitic (2%), antiallergic (2%), antiviral (2%), antiosteoporotic (2%), and antituberculosis (2%) activities. Of these, the antioxidant, antituberculosis, and anti-inflammatory activities of extract were weaker compared with that of the control drugs; however, other activities, particularly cytotoxicity, show promise, and the compounds responsible may be developed into new drugs.

摘要

海绵是海洋中分布最广泛的生物群落之一。 是一种在海洋中发现的海绵属，很容易获得。在本综述中，探讨了 属物种次生代谢产物的药理活性和作用机制，这可能会促成新药和靶向治疗方法的开发。我们挖掘了几个科学数据库，如谷歌学术、PubMed、ResearchGate、科学Direct、Springer Link和Wiley在线图书馆，以获取相关信息。在所综述的41篇文章中，据报道 属物种具有多种药理活性，如对癌细胞系的细胞毒性（36%）、抗真菌（10%）、抗炎（10%）、免疫调节（10%）、抗糖尿病和抗肥胖（6%）、抗菌（8%）、抗氧化（4%）、抗神经退行性（4%）、抗高胆固醇血症（2%）、抗高血压（2%）、抗寄生虫（2%）、抗过敏（2%）、抗病毒（2%）、抗骨质疏松（2%）和抗结核（2%）活性。其中， 提取物的抗氧化、抗结核和抗炎活性与对照药物相比较弱；然而，其他活性，特别是细胞毒性，显示出前景，相关化合物可能被开发成新药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/e059563e0447/metabolites-13-00217-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/3051a84f4c92/metabolites-13-00217-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/b152c8a75e57/metabolites-13-00217-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/260950bf1c2b/metabolites-13-00217-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/ec2519a7ad6c/metabolites-13-00217-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/39ee383a70e5/metabolites-13-00217-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/dd65438154a0/metabolites-13-00217-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/4d020eff6035/metabolites-13-00217-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/1e0da71b6629/metabolites-13-00217-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/5b1a19da5442/metabolites-13-00217-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/4fb8d726d854/metabolites-13-00217-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/88969c360cff/metabolites-13-00217-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/3b8c435f6daf/metabolites-13-00217-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/e059563e0447/metabolites-13-00217-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/3051a84f4c92/metabolites-13-00217-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/b152c8a75e57/metabolites-13-00217-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/260950bf1c2b/metabolites-13-00217-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/ec2519a7ad6c/metabolites-13-00217-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/39ee383a70e5/metabolites-13-00217-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/dd65438154a0/metabolites-13-00217-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/4d020eff6035/metabolites-13-00217-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/1e0da71b6629/metabolites-13-00217-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/5b1a19da5442/metabolites-13-00217-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/4fb8d726d854/metabolites-13-00217-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/88969c360cff/metabolites-13-00217-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/3b8c435f6daf/metabolites-13-00217-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1e/9964934/e059563e0447/metabolites-13-00217-g013.jpg

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