Z Naturforsch C J Biosci. 2014 Mar-Apr;69(3-4):117-23. doi: 10.5560/znc.2013-0088.
Two new polyacetylenes, callyspongenol-D (1) and callyspongendiol (2), the known polyacetylene dehydrosiphonochalynol (3), and the known triterpenoid sipholenol-A (4) were isolated from the Red Sea sponge Siphonochalina siphonella. Their chemical structures were elucidated on the basis of spectroscopic analyses. The cytotoxicity of the isolated compounds towards the human mammary carcinoma cell line MCF-7 was determined by the lactate dehydrogenase (LDH) assay, and compounds 4 and 1 were found to be the most toxic of the four, with IC50 values of 8.8 and 11.7 microM, respectively.
从红海海绵 Siphonochalina siphonella 中分离得到了两种新的聚乙炔类化合物，分别为 callyspongenol-D（1）和 callyspongendiol（2），已知的聚乙炔脱水硅氢醇（3）和三萜 sipholenol-A（4）。基于光谱分析确定了它们的化学结构。通过乳酸脱氢酶（LDH）测定法测定了分离得到的化合物对人乳腺癌细胞系 MCF-7 的细胞毒性，结果表明化合物 4 和 1 是这四种化合物中最毒的，IC50 值分别为 8.8 和 11.7 μM。
