Division of Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Central Campus, Navrangpura, Ahmedabad, Gujarat -380009, India.
Curr Drug Metab. 2019;20(6):473-482. doi: 10.2174/1389200219666181022163424.
Leishmaniasis is a dreaded disease caused by protozoan parasites belonging to the genus Leishmania which results in significant morbidity and mortality worldwide. There are no vaccines available currently for the treatment of Leishmaniasis and chemotherapy still remains the mainstay for anti-leishmanial therapeutics. However, toxicity, reduced bioavailability, high cost and chemoresistance are the principal problems which limit the use of the available drugs. In this context, anti-leishmanial nanotherapeutics may show the way for effective treatment of this dreaded disease.
We carried out extensive literature search of bibliographic database using keywords strictly within the scope of the present study for peer reviewed research articles. We focused specifically on articles related to the application of nanotechnology in drug development, drug delivery and vaccine delivery for anti-leishmanial therapeutics.
This study shows the immense potential of the application of nanotechnology in the field of anti-leishmanial therapeutics. This will aid the targeted delivery of different drugs which is expected to increase the bioavailability, reduce toxicity and also address the problem of chemoresistance.
We surmise that exciting research in the field of anti-leishmanial nanotherapeutics is already showing the promise for effective applicability. Though direct use of nanoparticles as therapeutic agents does not seem to be a good option, the application of nanotechnology in this field for vaccine development is still in its early days. The nano based drug delivery system for anti-leishmanial therapeutics has evolved considerably over the past ten years and holds the potential to drastically change the landscape of anti-leishmanial therapeutics.
利什曼病是一种由原生动物寄生虫引起的可怕疾病，属于利什曼属，在全球范围内导致了很高的发病率和死亡率。目前尚无治疗利什曼病的疫苗，化疗仍然是抗利什曼病治疗的主要方法。然而，毒性、生物利用度降低、高成本和耐药性是限制现有药物使用的主要问题。在这种情况下，抗利什曼病的纳米疗法可能为有效治疗这种可怕的疾病开辟道路。
我们使用严格限定在本研究范围内的关键字，对文献数据库进行了广泛的文献检索，以查找同行评审的研究文章。我们特别关注与纳米技术在药物开发、药物输送和疫苗输送中的应用相关的文章，用于抗利什曼病治疗。
本研究表明纳米技术在抗利什曼病治疗领域具有巨大的应用潜力。这将有助于靶向输送不同的药物，预计这将提高生物利用度、降低毒性，并解决耐药性问题。
我们推测，抗利什曼病纳米疗法领域的令人兴奋的研究已经显示出有效应用的前景。虽然直接将纳米颗粒用作治疗剂似乎不是一个好的选择，但纳米技术在该领域的疫苗开发仍处于早期阶段。过去十年中，抗利什曼病的纳米药物输送系统已经有了相当大的发展，并有可能彻底改变抗利什曼病治疗的格局。
