Intasa-Ard Soontaree Grace, Ogawa Makoto
School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan, Rayong, Thailand.
School of Energy Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan, Rayong, Thailand.
Enzymes. 2018;44:117-136. doi: 10.1016/bs.enz.2018.08.003. Epub 2018 Oct 5.
The potential of layered silicates as drug carrier is overviewed. Due to their large surface area and expandable interlayer space to accommodate drug molecules, layered silicates have a potential as carrier of various molecules. In addition to the electrostatic interactions between negatively charged layered silicates and positively charged drug molecules, the organic modification of the surface of layered silicates has been applied to accommodate a variety of drug molecules not only cationic ones. The in vitro release experiment of the accommodated drug molecules has been reported under the acidic conditions. In order to discuss the future direction of layered silicates as drug carrier, materials' variation of layered silicates and their modification, and the reported stimuli-responsive hybrids based on layered silicates were introduced.
综述了层状硅酸盐作为药物载体的潜力。由于层状硅酸盐具有较大的表面积和可扩展的层间空间以容纳药物分子，因此其具有作为各种分子载体的潜力。除了带负电荷的层状硅酸盐与带正电荷的药物分子之间的静电相互作用外，层状硅酸盐表面的有机改性已被用于容纳各种药物分子，而不仅仅是阳离子药物分子。已经报道了在酸性条件下所容纳药物分子的体外释放实验。为了探讨层状硅酸盐作为药物载体的未来发展方向，介绍了层状硅酸盐材料的变化及其改性，以及报道的基于层状硅酸盐的刺激响应性杂化物。
