Costa R A, Casaux M L, Caffarena R D, Macías-Rioseco M, Schild C O, Fraga M, Riet-Correa F, Giannitti F
Instituto Nacional de Investigación Agropecuaria, Ruta 50 km 11, La Estanzuela, Colonia, Uruguay.
Instituto Nacional de Investigación Agropecuaria, Ruta 50 km 11, La Estanzuela, Colonia, Uruguay; Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA.
J Comp Pathol. 2018 Oct;164:32-36. doi: 10.1016/j.jcpa.2018.08.005. Epub 2018 Sep 12.
Salmonellosis is an enteric or multisystemic disease of global distribution that affects numerous animal species. Although Salmonella enterica has been associated with urinary tract lesions in man, information on urocystitis/ureteritis in cattle caused by salmonellae is lacking. This communication describes lesions of the inferior urinary tract in four Holstein calves with septicaemia caused by S. enterica subsp. enterica serotype Dublin. Examination of the urinary bladder revealed either diffuse irregular thickening (three cases) or petechiation (one case) of the mucosa. On histopathological examination, urocystitis with submucosal histiocytic, lymphocytic and plasmacytic infiltration and neutrophil transmigration through the urothelium was noted in all cases. In one case, a fibrinosuppurative ureteritis was detected. Salmonella Dublin was identified by culture, 16S rDNA sequencing and serotyping and Salmonella antigen was detected intralesionally by immunohistochemistry. Other lesions, indicative of septicaemia included hepatitis, enteritis, pericarditis, splenitis, lymphadenitis and pneumonia. We conclude that S. Dublin can be uropathogenic in cattle with septicaemia.
沙门氏菌病是一种在全球范围内分布的肠道或多系统疾病，可影响众多动物物种。虽然肠炎沙门氏菌与人类的泌尿系统病变有关，但关于沙门氏菌引起的牛膀胱炎/输尿管炎的信息却很缺乏。本文描述了4头患有由肠炎沙门氏菌亚种肠炎血清型都柏林引起的败血症的荷斯坦犊牛下泌尿系统的病变情况。对膀胱的检查发现，黏膜要么出现弥漫性不规则增厚（3例），要么出现瘀点（1例）。组织病理学检查显示，所有病例均有膀胱炎，伴有黏膜下组织细胞、淋巴细胞和浆细胞浸润，以及中性粒细胞穿过尿路上皮的迁移。在1例病例中，检测到纤维蛋白脓性输尿管炎。通过培养、16S rDNA测序和血清分型鉴定出都柏林沙门氏菌，并通过免疫组织化学在病变部位检测到沙门氏菌抗原。其他表明败血症的病变包括肝炎、肠炎、心包炎、脾炎、淋巴结炎和肺炎。我们得出结论，都柏林沙门氏菌在患有败血症的牛中可能具有尿路致病性。
