Setor de Patologia Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Setor de Patologia Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
J Comp Pathol. 2022 Jun;194:14-21. doi: 10.1016/j.jcpa.2022.03.004. Epub 2022 Apr 19.
Septicaemia is the main pathological manifestation of Salmonella infection in chinchillas (Chinchilla lanigera), although information on its pathology is limited. We now describe the gross, histological and immunohistochemical features of Salmonella enterica subspecies enterica serotype Typhimurium (S. Typhimurium) infection in ranched chinchillas. Eighty-five adult pregnant chinchillas had anorexia, prostration, weight loss, hyperthermia and abortion. Necropsy of 13 animals revealed splenomegaly, hepatomegaly, mesenteric lymphadenomegaly, prominent Peyer's patches, pulmonary oedema, white pinpoint lesions in multiple organs and petechiae in the urinary bladder. In all cases, histological lesions were consistent with septicaemia, characterized by acute necrotizing hepatitis, splenitis, lymphadenitis, cystitis, pneumonia, enterocolitis, gastritis and/or nephritis. Immunohistochemistry for Salmonella spp on seven cases revealed intralesional immunolabelling in all affected organs. Salmonella sp was isolated from liver, spleen, intestinal contents and blood of 10 chinchillas. Isolates of four animals were identified as S. Typhimurium.
败血症是沙雷氏菌感染龙猫（毛丝鼠）的主要病理表现，尽管有关其病理学的信息有限。我们现在描述了牧场饲养的龙猫感染沙门氏菌亚种肠炎血清型（鼠伤寒沙门氏菌）的大体、组织学和免疫组织化学特征。85 只成年怀孕龙猫出现食欲不振、衰弱、体重减轻、发热和流产。13 只动物的尸检显示脾肿大、肝肿大、肠系膜淋巴结肿大、派尔氏斑明显、肺水肿、多个器官出现白色针尖状病变和膀胱瘀点。在所有情况下，组织学病变均符合败血症，表现为急性坏死性肝炎、脾炎、淋巴结炎、膀胱炎、肺炎、肠炎、胃炎和/或肾炎。对 7 例进行的沙门氏菌属免疫组织化学检查显示，所有受影响的器官均有局灶性免疫标记。从 10 只龙猫的肝脏、脾脏、肠内容物和血液中分离出沙门氏菌。4 只动物的分离物被鉴定为鼠伤寒沙门氏菌。
