Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.
Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
J Clin Lipidol. 2019 Jan-Feb;13(1):70-79.e1. doi: 10.1016/j.jacl.2018.09.013. Epub 2018 Sep 25.
Observational studies have reported inconsistent results on the association between circulating fatty acids and obesity.
The objective of this study was to investigate the relationship between erythrocyte phospholipid fatty acid composition and obesity in children and adolescents.
We conducted a case-control study including 1442 obese and 1442 normal-weight children and adolescents. Circulating fatty acid composition between cases and controls were compared both in the present study and literature-based meta-analysis. Individual fatty acids contributing most to discriminating cases and controls were identified by orthogonal partial least squares-discriminant analysis and their associations with obesity were explored by a conditional logistic regression model.
Five saturated fatty acids (14:0, 16:0, 17:0, 18:0, 20:0) were higher, 9 polyunsaturated fatty acids (18:3n-3, 20:3n-3, 20:5n-3, 22:5n-3, 22:6n-3, 18:2n-6, 20:2n-6, 20:3n-6, 20:4n-6) were lower in cases than in controls, while pooled results from the comparative meta-analysis were only consistent in 22:5n-3, 22:6n-3 and 18:2n-6. The orthogonal partial least squares-discriminant analysis model indicated that 16:0, 18:0, 20:4n-6, and 22:6n-3 were the fatty acids contributing most to discriminating cases and controls. In the conditional logistic regression model, significant positive associations were found for 16:0 (per 1 SD OR = 1.43, 95% CI, 1.35-1.52) and 18:0 (per 1 SD OR = 1.12, 95% CI, 1.09-1.16), while significant inverse associations were found for 20:4n-6 (per 1 SD OR = 0.63, 95% CI, 0.58-0.69) and 22:6n-3 (per 1 SD OR = 0.56, 95% CI, 0.52-0.61).
Erythrocyte phospholipid 16:0 and 18:0 were positively and 20:4n-6 and 22:6n-3 were inversely associated with obesity in children and adolescents.
观察性研究报告称，循环脂肪酸与肥胖之间的关联结果不一致。
本研究旨在探讨儿童和青少年红细胞磷脂脂肪酸组成与肥胖之间的关系。
我们进行了一项病例对照研究，纳入了 1442 名肥胖儿童和 1442 名正常体重儿童。比较了病例组和对照组之间的循环脂肪酸组成，并在文献基础上进行了荟萃分析。通过正交偏最小二乘判别分析确定对区分病例组和对照组贡献最大的个体脂肪酸，并通过条件 logistic 回归模型探讨其与肥胖的关系。
与对照组相比，5 种饱和脂肪酸（14:0、16:0、17:0、18:0、20:0）较高，9 种多不饱和脂肪酸（18:3n-3、20:3n-3、20:5n-3、22:5n-3、22:6n-3、18:2n-6、20:2n-6、20:3n-6、20:4n-6）较低，而荟萃分析的汇总结果仅在 22:5n-3、22:6n-3 和 18:2n-6 中一致。正交偏最小二乘判别分析模型表明，16:0、18:0、20:4n-6 和 22:6n-3 是对区分病例组和对照组贡献最大的脂肪酸。在条件 logistic 回归模型中，16:0（每 1 SD OR=1.43，95%CI，1.35-1.52）和 18:0（每 1 SD OR=1.12，95%CI，1.09-1.16）呈显著正相关，而 20:4n-6（每 1 SD OR=0.63，95%CI，0.58-0.69）和 22:6n-3（每 1 SD OR=0.56，95%CI，0.52-0.61）呈显著负相关。
儿童和青少年红细胞磷脂 16:0 和 18:0 与肥胖呈正相关，而 20:4n-6 和 22:6n-3 与肥胖呈负相关。
