Matsuno T, Orita K, Sato E, Nobori K, Inoue B, Utsumi K
Biochem Pharmacol. 1987 May 15;36(10):1613-6. doi: 10.1016/0006-2952(87)90044-x.
Effects of biscoclaurine alkaloids on the various stimulus-responses of PMN, especially on the O2-. generation of PMN, were investigated. Results obtained were: cepharanthine inhibited various metabolic responses of PMN, its biological action probably being due to its membrane modifying action. Inhibition of O2-. generation by cepharanthine was stronger than any other inhibition of metabolic responses of PMN. The inhibitory effect of various biscoclaurine alkaloids on the O2-. generation of PMN was the descending order of tri-, di- and mono-ether type; the coclaurine type showed only a weak effect.
研究了双苄基异喹啉生物碱对中性粒细胞各种刺激反应的影响，特别是对中性粒细胞O2-产生的影响。得到的结果如下：千金藤素抑制中性粒细胞的各种代谢反应，其生物学作用可能归因于其对细胞膜的修饰作用。千金藤素对O2-产生的抑制作用强于对中性粒细胞其他代谢反应的抑制作用。各种双苄基异喹啉生物碱对中性粒细胞O2-产生的抑制作用顺序为：三醚型＞二醚型＞单醚型；乌药碱型的作用较弱。
