Pinto de Moraes H, Herrera G A, Mendonca A M, Estrela R R
Appl Pathol. 1986;4(3):199-208.
Malignant mixed tumors of the skin (chondroid syringoma) are exceedingly rare. Few reports can be found in the literature and there are only two published cases in which electron microscopy has been performed. The precise histogenesis of this neoplasm is still disputed and the nature and mechanism of secretion of the intercellular substance is unknown as yet. Some authors believe that in mixed tumors of salivary glands this material could be produced by myoepithelial cells. A case is reported in which ultrastructural and immunocytochemical studies were performed in an effort to elucidate the histogenesis of malignant mixed tumors of skin and their relationship to other benign mixed tumors of the skin and salivary glands. The new information that has been obtained is interpreted in light of the findings provided by all published reports of malignant mixed tumors of the skin.
皮肤恶性混合瘤（软骨样汗腺螺旋瘤）极为罕见。文献中相关报道极少，仅有两篇已发表的病例进行了电子显微镜检查。该肿瘤的确切组织发生仍存在争议，细胞间质的分泌性质和机制尚不清楚。一些作者认为，在唾液腺混合瘤中，这种物质可能由肌上皮细胞产生。本文报道了一例通过超微结构和免疫细胞化学研究，试图阐明皮肤恶性混合瘤的组织发生及其与其他皮肤和唾液腺良性混合瘤关系的病例。根据所有已发表的皮肤恶性混合瘤报告所提供的研究结果，对所获得的新信息进行了解读。
