子宫内膜癌中的血管侵犯是其向宫颈扩散的机制之一。

Blood Vessel Invasion in Endometrial Cancer Is One of the Mechanisms of Spread to the Cervix.

机构信息

Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Department of Pathology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.

出版信息

Pathol Oncol Res. 2019 Oct;25(4):1431-1436. doi: 10.1007/s12253-018-0498-1. Epub 2018 Oct 25.

DOI:10.1007/s12253-018-0498-1

PMID:30361902

Abstract

To evaluate the association between type of invaded vessels (blood or lymphatic) and cervical involvement in endometrial cancer (EC). Pathological slides of 93 patients with EC who had vascular space invasion in hematoxylin-eosin staining underwent immunohistochemical assay with CD31 and podoplanin. CD31 and podoplanin were used to identify blood and lymphatic invaded vessels, respectively. Cervical stromal invasion (CSI) was determined in 21 (30%) patients. The rate of CD31-positivity was significantly higher in patients with CSI than without (76.2 and 34.7%, p = 0.001; respectively). Podoplanin-positivity was determined in 47.6 and 81.6% of patients with and without CSI, respectively (p = 0.005). Age, myometrial invasion and the combination of CD31-positivity with podoplanin-negativity were found as independent predictors for CSI. Blood vessel invasion is an important factor for CSI in EC. Blood vessel invasion rather than lymphatic vessel invasion is one of the predominant ways by which EC spreads to the cervix.

摘要

评估血管受侵类型（血液或淋巴）与子宫内膜癌（EC）宫颈受累的关系。对 93 例 EC 患者的病理切片进行 CD31 和 podoplanin 的免疫组化检测，这些患者在苏木精-伊红染色中存在血管腔侵犯。CD31 和 podoplanin 分别用于识别血液和淋巴侵袭性血管。21 例（30%）患者存在宫颈间质浸润（CSI）。在有 CSI 的患者中，CD31 阳性率明显高于无 CSI 的患者（76.2%和 34.7%，p=0.001）。有 CSI 的患者中 podoplanin 阳性率为 47.6%，无 CSI 的患者中为 81.6%（p=0.005）。年龄、肌层浸润以及 CD31 阳性与 podoplanin 阴性的组合被确定为 CSI 的独立预测因素。血管侵犯是 EC 发生 CSI 的重要因素。血管侵犯而不是淋巴管侵犯是 EC 向宫颈扩散的主要途径之一。