Sebastiani G, García-Beltran C, Pie S, Guerra A, López-Bermejo A, de Toledo J S, de Zegher F, Rosés F, Ibáñez L
Endocrinology Unit, Pediatric Research Institute Sant Joan de Déu, University of Barcelona, Esplugues, Spain.
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Health Institute Carlos III, Madrid, Spain.
Pediatr Obes. 2019 Mar;14(3):e12476. doi: 10.1111/ijpo.12476. Epub 2018 Oct 25.
The sequence of prenatal growth restraint and postnatal catch-up growth leads to a thicker intima-media and more pre-peritoneal fat by age 3-6 years.
To study whether carotid intima-media thickness (cIMT) and pre-peritoneal fat differ already between catch-up small-for-gestational-age (SGA) infants and appropriate-for-gestational-age (AGA) controls in late infancy (ages 1 and 2 years) and whether such differences - if any - are accompanied by differences in cardiac morphology and function.
Longitudinal assessments included body height and weight; fasting glucose, insulin, Insulin-like growth factor (IGF-I), high-molecular-weight adiponectin; body composition (by absorptiometry); cIMT, aortic IMT, pre-peritoneal fat partitioning (by ultrasound); cardiac morphometry and function (by echocardiography) in AGA and SGA infants at birth, at age 1 year (N = 87), and again at age 2 years (N = 68).
Catch-up SGA infants had already a thicker cIMT than AGA controls at ages 1 and 2 years, and more pre-peritoneal fat by age 2 years (all p values between <0.01 and <0.0001); all cardiac and endocrine-metabolic results were similar in AGA and SGA infants at ages 1 and 2 years.
From late infancy onwards, catch-up SGA infants have a thicker cIMT and more pre-peritoneal fat than AGA controls, but their cardiac morphology and function remain reassuringly similar.
产前生长受限及产后追赶生长的过程会导致3至6岁时内膜中层增厚及腹膜前脂肪增多。
研究在婴儿晚期（1岁和2岁），追赶生长的小于胎龄儿（SGA）与适于胎龄儿（AGA）对照之间颈动脉内膜中层厚度（cIMT）和腹膜前脂肪是否已经存在差异，以及此类差异（若存在）是否伴有心脏形态和功能的差异。
纵向评估包括身高和体重；空腹血糖、胰岛素、胰岛素样生长因子（IGF-I）、高分子量脂联素；身体成分（通过吸收测定法）；cIMT、主动脉IMT、腹膜前脂肪分布（通过超声）；对AGA和SGA婴儿在出生时、1岁时（N = 87）以及2岁时（N = 68）进行心脏形态测量和功能（通过超声心动图）评估。
追赶生长的SGA婴儿在1岁和2岁时cIMT就已经比AGA对照更厚，到2岁时腹膜前脂肪更多（所有p值在<0.01至<0.0001之间）；1岁和2岁时AGA和SGA婴儿的所有心脏及内分泌代谢结果相似。
从婴儿晚期起，追赶生长的SGA婴儿比AGA对照的cIMT更厚且腹膜前脂肪更多，但他们的心脏形态和功能仍令人放心地相似。
