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艾滋病毒/艾滋病可治愈研究:治疗三位一体的新形式。

HIV/AIDS Curable Study: New Forms of Therapeutic Trinity.

作者信息

Lu Da-Yong, Lu Ting-Ren, Wu Hong-Ying, Yarla Nagendra S, Ding Jian, Xu Bin

机构信息

Shanghai University, Shanghai 200444, China.

Divisions of Biochemistry & Chemistry, City University of New York School of Medicine, 160 Convent Avenue, New York, NY10031, United States.

出版信息

Recent Pat Antiinfect Drug Discov. 2018;13(3):217-227. doi: 10.2174/1574891X13666181026094526.

Abstract

BACKGROUND AND AIMS

AIDS (acquired immune deficient syndrome), a deadly human infectious disease is caused by HIV (human immunodeficiency viruses) infection. Patient's mortality was eventually reduced to one-fourth by combined chemotherapy (usually 3 chemical drugs simultaneously) than earlier HIV/AIDS treatments (single drug or vaccine) in the clinic.

RESULTS

Combined treatments against HIV/AIDS are still incurable for all patients despite a high rate of patient's survival. Basic viral pathological study and advancing drug development systems for curable medications are indispensable nowadays and in the future.

CONCLUSION

Up to date, therapeutic trinity (combined therapy) against HIV/AIDS is generally among chemical drugs. In this article, several forms of other therapeutic attempts for effectively curing efforts against HIV/AIDS are proposed-including the development of next generation therapeutic HIV vaccines and schedules, new categories of bio-therapy, different pathways of immune-modulation, herbal medicines in general (allopathic, Ayurveda and traditional Chinese medicines), high quality of physical exercises, and especially therapeutic combinations guided by latest medical discovery and principles (new forms of therapeutic trinity against HIV-induced pathogenesis and human mortality).

摘要

背景与目的

艾滋病(获得性免疫缺陷综合征)是一种致命的人类传染病,由人类免疫缺陷病毒(HIV)感染引起。与早期在临床中使用的HIV/AIDS治疗方法(单一药物或疫苗)相比,联合化疗(通常同时使用三种化学药物)最终使患者死亡率降低至四分之一。

结果

尽管患者存活率较高,但针对HIV/AIDS的联合治疗对所有患者来说仍然无法治愈。如今及未来,基础病毒病理学研究和推进可治愈药物的研发系统都是必不可少的。

结论

迄今为止,针对HIV/AIDS的治疗三联法(联合疗法)通常是在化学药物之间进行。在本文中,提出了几种其他治疗尝试的形式,旨在有效治愈HIV/AIDS,包括开发下一代治疗性HIV疫苗及其方案、新型生物疗法、不同的免疫调节途径、一般草药(对抗疗法、阿育吠陀医学和传统中药)、高质量体育锻炼,尤其是以最新医学发现和原则为指导的治疗组合(针对HIV诱导的发病机制和人类死亡率的新型治疗三联法)。

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