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咪唑二氮䓬Ro 15 - 4513对地西泮、戊巴比妥钠和乙醇抗惊厥作用的影响。

The effect of the imidazodiazepine Ro 15-4513 on the anticonvulsant effects of diazepam, sodium pentobarbital and ethanol.

作者信息

Nutt D J, Lister R G

出版信息

Brain Res. 1987 Jun 9;413(1):193-6. doi: 10.1016/0006-8993(87)90170-3.

DOI:10.1016/0006-8993(87)90170-3
PMID:3036316
Abstract

The ability of the imidazodiazepine Ro 15-4513 to antagonize the anticonvulsant effects of diazepam, sodium pentobarbital and ethanol was investigated. Ro 15-4513 alone significantly lowered seizure threshold to bicuculline and this effect subtracted from the anticonvulsant effects of sodium pentobarbital and ethanol. In contrast, Ro 15-4513 completely reversed the anticonvulsant effects of diazepam, consistent with suggestions that it is a competitive ligand for benzodiazepine receptors.

摘要

研究了咪唑二氮䓬Ro 15 - 4513拮抗地西泮、戊巴比妥钠和乙醇抗惊厥作用的能力。单独使用Ro 15 - 4513可显著降低对荷包牡丹碱的惊厥阈值，且该作用会削弱戊巴比妥钠和乙醇的抗惊厥作用。相比之下，Ro 15 - 4513完全逆转了地西泮的抗惊厥作用，这与它是苯二氮䓬受体竞争性配体的观点一致。

相似文献

1
The effect of the imidazodiazepine Ro 15-4513 on the anticonvulsant effects of diazepam, sodium pentobarbital and ethanol.咪唑二氮䓬Ro 15 - 4513对地西泮、戊巴比妥钠和乙醇抗惊厥作用的影响。
Brain Res. 1987 Jun 9;413(1):193-6. doi: 10.1016/0006-8993(87)90170-3.
2
Antagonizing the anticonvulsant effect of ethanol using drugs acting at the benzodiazepine/GABA receptor complex.使用作用于苯二氮䓬/GABA受体复合物的药物对抗乙醇的抗惊厥作用。
Pharmacol Biochem Behav. 1988 Nov;31(3):751-5. doi: 10.1016/0091-3057(88)90260-2.
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Interactions of Ro 15-4513 with diazepam, sodium pentobarbital and ethanol in a holeboard test.Ro 15-4513在洞板试验中与地西泮、戊巴比妥钠和乙醇的相互作用。
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Antagonism of ethanol and pentobarbital actions by benzodiazepine inverse agonists: neurochemical studies.苯二氮䓬反向激动剂对乙醇和戊巴比妥作用的拮抗作用：神经化学研究
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Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.咪唑二氮䓬Ro 15-4513与化学惊厥剂的相互作用。
Br J Pharmacol. 1988 Jan;93(1):210-4. doi: 10.1111/j.1476-5381.1988.tb11423.x.
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Chronic ethanol treatment alters the behavioral effects of Ro 15-4513, a partially negative ligand for benzodiazepine binding sites.长期乙醇处理会改变Ro 15-4513（一种苯二氮䓬结合位点的部分负性配体）的行为效应。
Brain Res. 1989 Jun 5;489(1):93-100. doi: 10.1016/0006-8993(89)90011-5.
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Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital.
Life Sci. 1987 Aug 3;41(5):611-9. doi: 10.1016/0024-3205(87)90415-2.
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Interactions of diazepam and pentobarbital with RO 15-4513 on intracranial self-stimulation discrimination behavior in rats.
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Differential interactions of Ro 15-4513 with benzodiazepines, ethanol and pentobarbital.
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RO15-4513 but not FG-7142 reverses anticonvulsant effects of ethanol against bicuculline- and picrotoxin-induced convulsions in rats.
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