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[50兆电子伏特氘核以及34、45、65和75兆电子伏特质子产生的中子的相对生物效应(RBE)]

[Relative biological effectiveness (RBE) of neutrons produced by 50 MeV deuterons and by 34, 45, 65 and 75 MeV protons].

作者信息

Beauduin M, Gueulette J, De Coster B M, Octave-Prignot M, Vynckier S, Wambersie A

出版信息

C R Seances Soc Biol Fil. 1987;181(1):78-81.

PMID:3036323
Abstract

RBE of p(34) + Be, p(45) + Be, p(65), + Be, p(75) + Be and d(50) + Be neutron beams produced at the cyclotron "Cyclone" of Louvain-la-Neuve were measured. The biological criterion was the regeneration of the crypts of the intestinal mucosa (50 regenerated crypts per circumference) after abdominal irradiation in mice. Taking the p(65) + Be neutrons as reference, RBE values were found equal to 1.12, 1.07, 1.00 (Ref.), 0.96 and 1.02 respectively. These results are consistent with those published for cell lethality in vitro. However, the RBE variation is smaller than this previously obtained in the laboratory for growth inhibition in Vicia faba.

摘要

对在鲁汶新大学的“Cyclone”回旋加速器产生的p(34)+铍、p(45)+铍、p(65)+铍、p(75)+铍和d(50)+铍中子束的相对生物学效应(RBE)进行了测量。生物学标准是小鼠腹部照射后肠黏膜隐窝的再生(每周长50个再生隐窝)。以p(65)+铍中子为参考,发现RBE值分别等于1.12、1.07、1.00(参考值)、0.96和1.02。这些结果与体外细胞致死率发表的结果一致。然而,RBE的变化比该实验室之前在蚕豆生长抑制实验中获得的变化要小。

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