Woods Damith T, Kneebone Anthony C
Faculty of Psychology, Cognition and Cognitive Neuroscience Laboratory Chulalongkorn University Bangkok Thailand.
Flinders Medical Center Department of Clinical Neuropsychology South Australia Australia.
Mov Disord Clin Pract. 2016 Nov 20;4(3):430-436. doi: 10.1002/mdc3.12452. eCollection 2017 May-Jun.
The purpose of this study was to examine differences in patient and caregiver ratings of memory function in a community sample of patients with Parkinson's disease (PD) diagnosed with and without mild cognitive impairment (PD-MCI).
One hundred sixty-five patient-caregiver pairings participated in the study. Patients with PD were administered a battery of neuropsychological tests assessing five of the key cognitive domains as indicated in the PD-MCI Movement Disorders Task Force criteria. Patients and caregivers also completed the Memory Assessment Clinics Self-Rating or Family Scale (MAC-S/MAC-F), and patients were divided into two groups, those with PD-MCI and those without.
For patients diagnosed with PD-MCI, both patients and caregivers reported significantly more memory changes compared with patients without PD-MCI on the MAC-S and MAC-F. In contrast, for patients without PD-MCI, patients and caregivers differed significantly in their reporting of memory changes, with scores indicating that patients without PD-MCI felt their memory functioning was worse than what caregivers were reporting.
Patients with PD without MCI might be more sensitive to memory changes than their caregivers. Whether the self-appraisal of memory problems is predictive of future cognitive difficulties, including progression to PD-MCI or PD dementia, should be the focus of future research.
本研究的目的是检验在诊断为有或无轻度认知障碍（PD-MCI）的帕金森病（PD）社区患者样本中，患者与照料者对记忆功能评分的差异。
165对患者-照料者参与了本研究。按照PD-MCI运动障碍特别工作组标准，对PD患者进行了一系列神经心理学测试，以评估五个关键认知领域。患者和照料者还完成了记忆评估诊所自评或家庭量表（MAC-S/MAC-F），患者被分为两组，即有PD-MCI组和无PD-MCI组。
对于诊断为PD-MCI的患者，与无PD-MCI的患者相比，患者和照料者在MAC-S和MAC-F上均报告有明显更多的记忆变化。相比之下，对于无PD-MCI的患者，患者和照料者在报告记忆变化方面存在显著差异，分数表明无PD-MCI的患者感觉自己的记忆功能比照料者报告的更差。
无MCI的PD患者可能比其照料者对记忆变化更敏感。记忆问题的自我评估是否能预测未来的认知困难，包括进展为PD-MCI或PD痴呆，应是未来研究的重点。
