Division of Movement Disorders, Department of Neurology, University of Louisville, Louisville, Kentucky, USA.
Mov Disord. 2012 Mar;27(3):349-56. doi: 10.1002/mds.24893. Epub 2012 Jan 24.
Mild cognitive impairment is common in nondemented Parkinson's disease (PD) patients and may be a harbinger of dementia. In view of its importance, the Movement Disorder Society commissioned a task force to delineate diagnostic criteria for mild cognitive impairment in PD. The proposed diagnostic criteria are based on a literature review and expert consensus. This article provides guidelines to characterize the clinical syndrome and methods for its diagnosis. The criteria will require validation, and possibly refinement, as additional research improves our understanding of the epidemiology, presentation, neurobiology, assessment, and long-term course of this clinical syndrome. These diagnostic criteria will support future research efforts to identify at the earliest stage those PD patients at increased risk of progressive cognitive decline and dementia who may benefit from clinical interventions at a predementia stage.
轻度认知障碍在非痴呆帕金森病 (PD) 患者中很常见,可能是痴呆的先兆。鉴于其重要性,运动障碍学会委托一个工作组来划定 PD 患者轻度认知障碍的诊断标准。拟议的诊断标准基于文献回顾和专家共识。本文提供了描述临床综合征特征的指南和诊断方法。随着进一步研究提高我们对该临床综合征的流行病学、表现、神经生物学、评估和长期病程的认识,这些标准可能需要验证和完善。这些诊断标准将支持未来的研究工作,以便在认知能力下降和痴呆风险增加的 PD 患者中尽早识别,并在痴呆前期阶段对其进行临床干预。