多巴胺受体D3基因rs6280与帕金森病的异常决策有关。
Dopamine Receptor D3 rs6280 is Associated with Aberrant Decision-Making in Parkinson's Disease.
作者信息
Rajan Roopa, Krishnan Syam, Sarma Gangadhara, Sarma Sankara P, Kishore Asha
机构信息
Comprehensive Care Center for Movement Disorders Sree Chitra Tirunal Institute for Medical Sciences and Technology Trivandrum Kerala India.
Achutha Menon Centre for Public Health Studies Sree Chitra Tirunal Institute for Medical Sciences and Technology Trivandrum Kerala India.
出版信息
Mov Disord Clin Pract. 2018 Jul 19;5(4):413-416. doi: 10.1002/mdc3.12631. eCollection 2018 Jul-Aug.
BACKGROUND
The functional Ser9Gly single nucleotide polymorphism (SNP) in the dopamine D3 receptor gene is associated with impulse control disorders (ICD) in Parkinson's disease (PD) in Indian patients. Whether the same SNP modulates impulsivity in PD patients without active ICD is unknown. We aimed to compare decision-making under uncertainty in PD patients with DRD3 p.S9G (rs6280) variants CT/CC or TT.
METHODS
We conducted a cross-sectional study including PD patients (n = 78) whose DRD3 p.S9G (rs6280) genotypic status was known (CC, CT, and TT). Decision-making was assessed using the Iowa Gambling Task (IGT).
RESULTS
IGT total ( 0.267) or block scores did not differ between the DRD3 rs6280 variant groups. Deck choice analysis revealed that the CT/CC group showed a skewed preference in deck choice ( 0.002) due to significantly fewer draws from deck B, compared to all other decks (deck A, 0.001; deck C, 0.004; deck D, 0.002).
CONCLUSIONS
The functional Ser9Gly DRD3 variant is associated with aberrant decision-making under uncertainty in PD patients without active ICD. This ability to modulate impulsivity may underlie its association with clinical ICD in PD.
背景
多巴胺D3受体基因中功能性Ser9Gly单核苷酸多态性（SNP）与印度帕金森病（PD）患者的冲动控制障碍（ICD）相关。对于无活动性ICD的PD患者，同一SNP是否调节冲动性尚不清楚。我们旨在比较携带DRD3 p.S9G（rs6280）变异CT/CC或TT的PD患者在不确定性下的决策情况。
方法
我们进行了一项横断面研究，纳入了78例已知DRD3 p.S9G（rs6280）基因型状态（CC、CT和TT）的PD患者。使用爱荷华赌博任务（IGT）评估决策情况。
结果
DRD3 rs6280变异组之间的IGT总分（0.267）或分组得分没有差异。牌组选择分析显示，与所有其他牌组相比（牌组A，0.001；牌组C，0.004；牌组D，0.002），CT/CC组在牌组选择上表现出偏态偏好（0.002），因为从牌组B抽取的次数明显更少。
结论
功能性Ser9Gly DRD3变异与无活动性ICD的PD患者在不确定性下的异常决策相关。这种调节冲动性的能力可能是其与PD临床ICD相关的基础。
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