Sharma Vibhash D, Bona Alberto R, Mantovani Alessandra, Miocinovic Svjetlana, Khemani Pravin, Goldberg Mark P, Foote Kelly D, Whitworth Louis A, Chitnis Shilpa, Okun Michael S
Department of Neurology Emory University School of Medicine Atlanta Georgia USA.
Center for Movement Disorders and Neurorestoration University of Florida Gainesville Florida USA.
Mov Disord Clin Pract. 2015 Sep 16;3(1):87-90. doi: 10.1002/mdc3.12230. eCollection 2016 Jan-Feb.
DBS is a typically well-tolerated operation for treatment of Parkinson's disease, dystonia, and essential tremor (ET). Complications related to the surgical procedure and implanted hardware may occur. More commonly reported complications include hemorrhage, seizure, confusion, and infection. In this article, we report on a rare, but important, complication of DBS surgery, a brain cyst formation at the tip of the implanted ventralis intermedius nucleus (VIM) DBS lead in 2 patients who underwent the procedure at 2 different centers. The indication for surgery was debilitating ET, and in both cases, there was development of a delayed-onset neurological deficit associated with an internal capsule/thalamic cystic lesion formation located at the tip of the DBS lead. Case 1 presented within a few months post-DBS, whereas case 2 had a 10-mo delay to onset of symptoms. No clinical and radiological signs of infection were observed and both DBS systems were explanted with uneventful recovery.
脑深部电刺激术（DBS）是一种治疗帕金森病、肌张力障碍和特发性震颤（ET）时通常耐受性良好的手术。与手术操作和植入硬件相关的并发症可能会发生。更常报道的并发症包括出血、癫痫发作、意识模糊和感染。在本文中，我们报告了DBS手术一种罕见但重要的并发症，在2个不同中心接受该手术的2例患者中，植入的腹中间核（VIM）DBS电极尖端形成了脑囊肿。手术指征为严重的ET，在这2例病例中，均出现了与位于DBS电极尖端的内囊/丘脑囊性病变形成相关的迟发性神经功能缺损。病例1在DBS术后数月内出现症状，而病例2在术后10个月出现症状。未观察到感染的临床和影像学迹象，两个DBS系统均被取出，恢复过程顺利。
