Lelli G, Casadio M, Giordani S, Giuliotti C, Canova N, Martoni A, Pannuti F
Chemioterapia. 1987 Apr;6(2):134-6.
Twenty-seven patients with small cell bronchogenic carcinoma were treated with a combination of 4'-Epidoxorubicin 60 mg/m2 and cisplatin 50 mg/m2 i.v. every 3-4 weeks. Three patients (11%) had a complete remission (CR), and 12 (44%) had a partial remission (PR) with a 55% overall remission rate. The median duration of response was 36 weeks (range 11-256+). No severe bone marrow depression was noted. The other side effects were of mild grade. Because of the "minimal aggressiveness" of this combination for the patients, the results obtained in this preliminary phase can probably be improved by the integration of other drugs in the scheme.
27例小细胞支气管癌患者接受了4'-表阿霉素60mg/m²和顺铂50mg/m²静脉注射联合治疗，每3 - 4周一次。3例患者（11%）完全缓解（CR），12例（44%）部分缓解（PR），总缓解率为55%。缓解的中位持续时间为36周（范围11 - 256+）。未观察到严重的骨髓抑制。其他副作用为轻度。由于该联合方案对患者的“侵袭性最小”，在该初步阶段获得的结果可能通过在方案中加入其他药物而得到改善。
