Université de Strasbourg, Centre Européen d'Etude du Diabète, DIATHEC EA 7294, Fédération de Médecine Translationnelle de Strasbourg, F-67000 Strasbourg, France.
Aérial, Illkirch, France.
Oxid Med Cell Longev. 2018 Sep 30;2018:7019573. doi: 10.1155/2018/7019573. eCollection 2018.
Oxidative stress (OS) plays a major role in type 2 diabetes and its vascular and hepatic complications, and novel therapeutic approaches include natural antioxidants. Our previous chemical and biological studies demonstrated the antioxidant activities of red cabbage (RC), and here, we aimed to determine the effects of 2-month long RC consumption using a high-fat/high-fructose model of diabetic rats.
This vegetable, associated with lifestyle measurement, was shown to decrease OS and increase vascular endothelial NO synthase expression, ensuring vascular homeostasis. In the liver, RC consumption decreased OS by inhibiting p22phox expression and Nrf2 degradation and increasing catalase activity. It inhibited the activation of SREBP (1c, 2), ChREBP, NF-B, ERK1/2, PPAR, and GS and SIRT1 decrease, as observed in diabetic rats.
CONCLUSION/INNOVATION: RC consumption led to metabolic profile improvement, together with hepatic function improvements. Although lifestyle changes are not sufficient to prevent diabetic complications, enrichment with RC avoids progression hepatic complications. This antioxidant strategy using RC does not only able to increase antioxidant defense, such as classical antioxidant, but also able to assure a metabolic and energetic balance to reverse complications. Whereas traditional medical therapy failed to reverse NASH in diabetic patients, consumption of RC should be a natural therapy to treat it.
氧化应激（OS）在 2 型糖尿病及其血管和肝脏并发症中起主要作用，新的治疗方法包括天然抗氧化剂。我们之前的化学和生物学研究表明，红甘蓝（RC）具有抗氧化活性，在此，我们旨在通过高脂肪/高果糖诱导的糖尿病大鼠模型确定 RC 连续食用 2 个月的效果。
这种与生活方式测量相关的蔬菜被证明可以降低 OS 并增加血管内皮一氧化氮合酶的表达，从而确保血管内稳态。在肝脏中，RC 通过抑制 p22phox 表达和 Nrf2 降解以及增加过氧化氢酶活性来降低 OS。它抑制 SREBP（1c、2）、ChREBP、NF-B、ERK1/2、PPAR 和 GS 的激活，以及糖尿病大鼠中 SIRT1 的减少。
结论/创新：RC 的摄入导致代谢谱的改善，同时改善肝功能。尽管生活方式的改变不足以预防糖尿病并发症，但 RC 的丰富可以避免肝脏并发症的进展。这种使用 RC 的抗氧化策略不仅能够增加抗氧化防御，如经典抗氧化剂，而且还能够确保代谢和能量平衡，以逆转并发症。虽然传统的医学疗法未能逆转糖尿病患者的 NASH，但 RC 的摄入应该是一种治疗 NASH 的自然疗法。
