Casero David, Sandoval Salemiz, Seet Christopher S, Scholes Jessica, Zhu Yuhua, Ha Vi Luan, Luong Annie, Parekh Chintan, Crooks Gay M
Department of Pathology &Laboratory Medicine, David Geffen School of Medicine University of California, Los Angeles, Los Angeles, California, USA.
Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Nat Immunol. 2015 Dec;16(12):1282-91. doi: 10.1038/ni.3299. Epub 2015 Oct 26.
To elucidate the transcriptional 'landscape' that regulates human lymphoid commitment during postnatal life, we used RNA sequencing to assemble the long non-coding transcriptome across human bone marrow and thymic progenitor cells spanning the earliest stages of B lymphoid and T lymphoid specification. Over 3,000 genes encoding previously unknown long non-coding RNAs (lncRNAs) were revealed through the analysis of these rare populations. Lymphoid commitment was characterized by lncRNA expression patterns that were highly stage specific and were more lineage specific than those of protein-coding genes. Protein-coding genes co-expressed with neighboring lncRNA genes showed enrichment for ontologies related to lymphoid differentiation. The exquisite cell-type specificity of global lncRNA expression patterns independently revealed new developmental relationships among the earliest progenitor cells in the human bone marrow and thymus.
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