Mansour-Ghanaei Roya, Mansour-Ghanaei Fariborz, Naghipour Mohammadreza, Joukar Farahnaz, Atrkar-Roushan Zahra, Tabatabaii Mohammadjavad, Ghorani Najmeh
Gastrointestinal & Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Caspian Digestive Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran.
J Med Life. 2018 Jul-Sep;11(3):194-202. doi: 10.25122/jml-2018-0031.
Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated health problem that causes other liver diseases for the patient. Four anthropometric indices: body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were analyzed as NAFLD predictors in the present study. From the total number of individuals who referred to the PERSIAN Guilan Cohort study (PGCS) located in the north of Iran during the period of study, a total of 960 people were enrolled in the present study. NAFLD was diagnosed using through an abdominal ultrasound exam. Height, weight, WC, BMI, WHR and WHtR were later calculated. Chi-square, ANOVA and logistic regression analyses were used to analyze the risk factors. Out of the 960 individuals who were enrolled in the study, 597 (62.2%) were male and 363 (37.8%) were female (with an average age of 47.21 ± 7.29 years). There was a significant relationship between weight and NAFLD (P<0.001). There was also a significant relationship between BMI (OR= 8.41; 95% CI = 5.59-12.75), WC (OR= 2.67; 95% CI = 2.05-3.48), WHR (OR= 3.84; 95% CI = 2.26-6.52), WHtR (OR= 28.53; 95% CI = 6.94-117.31) and NAFLD (P<0.001). The results of the logistic regression analysis showed that WHtR, BMI and WC were effective predictors for the risk of NAFLD while WHtR played a more important role in the prediction of NAFLD. Anthropometric indices, especially WHtR, as a simple screening tool, seem to be an important criterion for the detection of NAFLD.
非酒精性脂肪性肝病（NAFLD）是一种与肥胖相关的健康问题，会给患者带来其他肝脏疾病。在本研究中，分析了四个身体测量指标：体重指数（BMI）、腰围（WC）、腰臀比（WHR）和腰高比（WHtR）作为NAFLD的预测指标。在研究期间，从转诊至位于伊朗北部的波斯湾吉兰队列研究（PGCS）的个体总数中，共有960人纳入本研究。通过腹部超声检查诊断NAFLD。随后计算身高、体重、WC、BMI、WHR和WHtR。采用卡方检验、方差分析和逻辑回归分析来分析危险因素。在纳入研究的960名个体中，597名（62.2%）为男性，363名（37.8%）为女性（平均年龄47.21±7.29岁）。体重与NAFLD之间存在显著关系（P<0.001）。BMI（OR=8.41；95%CI=5.59-12.75）、WC（OR=2.67；95%CI=2.05-3.48）、WHR（OR=3.84；95%CI=2.26-6.52）、WHtR（OR=28.53；95%CI=6.94-117.31）与NAFLD之间也存在显著关系（P<0.001）。逻辑回归分析结果表明，WHtR、BMI和WC是NAFLD风险的有效预测指标，而WHtR在NAFLD预测中发挥着更重要的作用。身体测量指标，尤其是WHtR，作为一种简单的筛查工具，似乎是检测NAFLD的重要标准。
