Patel Jolly, Ringley J Tanner, Moore Donald C
Levine Cancer Institute, Atrium Health, Department of Pharmacy, Charlotte, NC, USA.
Pharmacist Clinical Coordinator - Oncology, Levine Cancer Institute, Atrium Health, Department of Pharmacy, 1021 Morehead Medical Drive, Charlotte, NC 28204, USA.
Ther Adv Drug Saf. 2018 May 21;9(8):495-498. doi: 10.1177/2042098618776911. eCollection 2018 Aug.
Palmar-plantar erythrodysesthesia, also known as hand-foot syndrome (HFS), is a well-known dermatologic adverse event that can occur with a variety of cytotoxic chemotherapies including fluoropyrimidines, cytarabine, liposomal doxorubicin, and taxanes. HFS often presents as painful erythemas and desquamation of the skin involving the palms of the hands and the soles of the feet. Three cases are presented of patients with breast cancer who received multiagent chemotherapy regimens containing docetaxel that developed an atypical presentation of HFS on the dorsal aspect of the hands and feet. All patients received supportive care to manage the symptoms of their dermatologic toxicity. Dorsal HFS improved with supportive care or dose reduction and resolved following completion of the docetaxel-based chemotherapy. Based on the temporal relationship of the event and previous reports, we found that docetaxel was the probable offending agent.
手足红斑性感觉异常，也称为手足综合征（HFS），是一种众所周知的皮肤不良事件，可发生于多种细胞毒性化疗药物，包括氟嘧啶、阿糖胞苷、脂质体阿霉素和紫杉烷类。HFS通常表现为累及手掌和足底的皮肤疼痛性红斑和脱屑。本文报告了3例乳腺癌患者，她们接受了含多西他赛的联合化疗方案，在手背和足背出现了非典型的HFS表现。所有患者均接受了支持治疗以控制皮肤毒性症状。通过支持治疗或剂量减少，手背HFS得到改善，并在基于多西他赛的化疗完成后消退。根据事件的时间关系和既往报道，我们发现多西他赛可能是致病因素。
