• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

除莠霉素A对纤连蛋白表达的增强作用。

Enhancement of fibronectin expression by herbimycin A.

作者信息

Umezawa K, Atsumi S, Matsushima T, Takeuchi T

出版信息

Experientia. 1987 Jun 15;43(6):614-6. doi: 10.1007/BF02126351.

DOI:10.1007/BF02126351
PMID:3036558
Abstract

Herbimycin A specifically increased the level of fibronectin mRNA in Rous sarcoma virus-infected rat kidney cells, and the time course of fibronectin expression was found to be closely related to that of morphological change induced by herbimycin A.

摘要

除莠霉素A特异性地提高了感染劳氏肉瘤病毒的大鼠肾细胞中纤连蛋白mRNA的水平，并且发现纤连蛋白表达的时间进程与除莠霉素A诱导的形态学变化的时间进程密切相关。

相似文献

1
Enhancement of fibronectin expression by herbimycin A.除莠霉素A对纤连蛋白表达的增强作用。
Experientia. 1987 Jun 15;43(6):614-6. doi: 10.1007/BF02126351.
2
Use and selectivity of herbimycin A as inhibitor of protein-tyrosine kinases.除草霉素A作为蛋白酪氨酸激酶抑制剂的用途及选择性。
Methods Enzymol. 1991;201:370-9. doi: 10.1016/0076-6879(91)01033-x.
3
Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase.筛选能将劳斯肉瘤病毒感染的大鼠肾细胞的“转化形态”转变为“正常形态”的试剂：鉴定出一种活性试剂为除草菌素及其对细胞内src激酶的抑制作用。
Jpn J Cancer Res. 1985 Aug;76(8):672-5.
4
A host-dependent temperature-sensitive mutant of Rous sarcoma virus: evidence for host factors affecting transformation.劳斯肉瘤病毒的一种宿主依赖性温度敏感突变体：影响转化的宿主因子的证据。
Virology. 1988 Oct;166(2):561-72. doi: 10.1016/0042-6822(88)90527-2.
5
Herbimycin A inhibits the association of p60v-src with the cytoskeletal structure and with phosphatidylinositol 3' kinase.除莠霉素A抑制p60v-src与细胞骨架结构以及磷脂酰肌醇3'激酶的结合。
Oncogene. 1993 Mar;8(3):559-64.
6
Induction of hsp 72/73 by herbimycin A, an inhibitor of transformation by tyrosine kinase oncogenes.酪氨酸激酶致癌基因转化抑制剂赫比霉素A对热休克蛋白72/73的诱导作用。
Exp Cell Res. 1991 Aug;195(2):338-44. doi: 10.1016/0014-4827(91)90382-5.
7
Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1.赫伯霉素A逆转劳氏肉瘤病毒转化的机制：由于激酶活性降低和p60v-src1周转增加导致总磷酸酪氨酸水平降低。
Cancer Res. 1989 Feb 15;49(4):780-5.
8
Induction by herbimycin A of contact inhibition in v-src-expressed cells.
J Antibiot (Tokyo). 1989 Dec;42(12):1831-7. doi: 10.7164/antibiotics.42.1831.
9
Stretch-induced overproduction of fibronectin in mesangial cells is mediated by the activation of mitogen-activated protein kinase.系膜细胞中拉伸诱导的纤连蛋白过度产生是由丝裂原活化蛋白激酶的激活介导的。
Diabetes. 1999 Mar;48(3):595-602. doi: 10.2337/diabetes.48.3.595.
10
A new activity of herbimycin A: inhibition of angiogenesis.赫比霉素A的一项新活性：抑制血管生成。
J Antibiot (Tokyo). 1989 Jun;42(6):1015-7. doi: 10.7164/antibiotics.42.1015.

引用本文的文献

1
Phospholipase C in mouse oocytes: characterization of beta and gamma isoforms and their possible involvement in sperm-induced Ca2+ spiking.小鼠卵母细胞中的磷脂酶C：β和γ亚型的特性及其在精子诱导的Ca2+ 峰值中的可能作用
Biochem J. 1996 Jun 1;316 ( Pt 2)(Pt 2):583-91. doi: 10.1042/bj3160583.
2
Herbimycin A suppresses the reduction of gap-junctional intercellular communication induced by tumor-promoting phorbol ester in 3T3-L1 cells.除莠霉素A可抑制促肿瘤佛波酯诱导的3T3-L1细胞间隙连接细胞间通讯的减少。
Jpn J Cancer Res. 1989 Sep;80(9):855-60. doi: 10.1111/j.1349-7006.1989.tb01726.x.

本文引用的文献

1
Cell surface interactions with extracellular materials.细胞表面与细胞外物质的相互作用。
Annu Rev Biochem. 1983;52:761-99. doi: 10.1146/annurev.bi.52.070183.003553.
2
Isolation and characterization of cDNA clones for human and bovine fibronectins.
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3218-22. doi: 10.1073/pnas.80.11.3218.
3
The nucleotide sequence of the rat cytoplasmic beta-actin gene.大鼠细胞质β-肌动蛋白基因的核苷酸序列。
Nucleic Acids Res. 1983 Mar 25;11(6):1759-71. doi: 10.1093/nar/11.6.1759.
4
Transcriptional control of the fibronectin gene in chick embryo fibroblasts transformed by Rous sarcoma virus.劳氏肉瘤病毒转化的鸡胚成纤维细胞中纤连蛋白基因的转录调控
J Biol Chem. 1983 May 10;258(9):5787-93.
5
Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase.筛选能将劳斯肉瘤病毒感染的大鼠肾细胞的“转化形态”转变为“正常形态”的试剂：鉴定出一种活性试剂为除草菌素及其对细胞内src激酶的抑制作用。
Jpn J Cancer Res. 1985 Aug;76(8):672-5.
6
Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.人纤连蛋白的一级结构：差异剪接可能从单个基因产生至少10种多肽。
EMBO J. 1985 Jul;4(7):1755-9. doi: 10.1002/j.1460-2075.1985.tb03847.x.
7
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.从富含核糖核酸酶的来源中分离生物活性核糖核酸。
Biochemistry. 1979 Nov 27;18(24):5294-9. doi: 10.1021/bi00591a005.
8
Relationships between fibronectin (LETS protein) and actin.
Cell. 1978 Nov;15(3):875-86. doi: 10.1016/0092-8674(78)90272-6.
9
Properties of mammalian cells transformed by temperature-sensitive mutants of avian sarcoma virus.
Cell. 1977 Jul;11(3):513-21. doi: 10.1016/0092-8674(77)90069-1.
10
Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts.细胞表面蛋白可部分恢复转化成纤维细胞的形态、黏附性及运动接触抑制。
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1217-21. doi: 10.1073/pnas.73.4.1217.