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筛选能将劳斯肉瘤病毒感染的大鼠肾细胞的“转化形态”转变为“正常形态”的试剂：鉴定出一种活性试剂为除草菌素及其对细胞内src激酶的抑制作用。

Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase.

作者信息

Uehara Y, Hori M, Takeuchi T, Umezawa H

出版信息

Jpn J Cancer Res. 1985 Aug;76(8):672-5.

PMID:3930444
Abstract

During the course of screening of agents active in converting the transformed morphology of Rous sarcoma virus-infected rat kidney cells to the normal morphology, we identified an active substance produced by Streptomyces sp. MH237-CF8 as herbimycin. Herbimycin converted almost all cells into the normal morphology. The antibiotic was found to be an inhibitor of p60src-associated protein kinase in the cells.

摘要

在筛选能够将劳斯肉瘤病毒感染的大鼠肾细胞的转化形态转变为正常形态的活性物质的过程中，我们鉴定出链霉菌属菌株MH237-CF8产生的一种活性物质为除草菌素。除草菌素几乎能将所有细胞转变为正常形态。结果发现这种抗生素是细胞中与p60src相关的蛋白激酶的抑制剂。

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Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase.筛选能将劳斯肉瘤病毒感染的大鼠肾细胞的“转化形态”转变为“正常形态”的试剂：鉴定出一种活性试剂为除草菌素及其对细胞内src激酶的抑制作用。
Jpn J Cancer Res. 1985 Aug;76(8):672-5.
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Inhibition of pp60c-src protein kinase by herbimycin A in polyomavirus middle tumor antigen-transformed cells.除草菌素A对多瘤病毒中肿瘤抗原转化细胞中pp60c-src蛋白激酶的抑制作用。
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Virology. 1988 Oct;166(2):561-72. doi: 10.1016/0042-6822(88)90527-2.

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