Cuellar-Barboza Adrian, Alberto Cardenas-De La Garza Jesus, Daniel Villarreal-Villarreal Cesar, Ocampo-Candiani Jorge, Gomez-Flores Minerva, Welsh Oliverio, Herz-Ruelas Maira E
J Drugs Dermatol. 2018 Oct 1;17(10):1123-1125.
Bullous morphea is rare clinical variant of localized scleroderma characterized by the formation of bullae on sclerotic morphea plaques. Severe disease may be highly disabling and greatly impair quality of life. Current treatment strategies are based on anecdotal reports of clinical experience and include topical corticosteroids, methotrexate and phototherapy. Herein, we describe the case of a 56-year-old woman with progressive bullous sclerotic lesions who was successfully treated with mycophenolate mofetil after treatment failure with psoralen plus ultraviolet A therapy, ultraviolet A1 phototherapy, and methotrexate. Treatment with mycophenolate mofetil halted disease progression after 8 weeks. No major adverse effects were recorded in a 3-year follow-up with continuous treatment. This case suggests mycophenolate mofetil may be considered as an alternative for the treatment of resistant bullous morphea lesions. J Drugs Dermatol. 2018;17(10):1123-1125.
大疱性硬斑病是局限性硬皮病的一种罕见临床变体，其特征是在硬化性硬斑病斑块上形成大疱。严重的疾病可能会导致高度残疾，并极大地损害生活质量。目前的治疗策略基于临床经验的轶事报道，包括外用皮质类固醇、甲氨蝶呤和光疗。在此，我们描述了一名56岁女性的病例，该患者患有进行性大疱性硬化性病变，在补骨脂素加紫外线A疗法、紫外线A1光疗和甲氨蝶呤治疗失败后，霉酚酸酯治疗成功。霉酚酸酯治疗8周后疾病进展停止。在持续治疗的3年随访中未记录到重大不良反应。该病例表明，霉酚酸酯可被视为治疗难治性大疱性硬斑病病变的一种替代方法。《药物皮肤病学杂志》。2018年；17(10):1123 - 1125。
